Adenoid cystic carcinoma of the head and neck - An update

Andrés Coca-Pelaz; Juan P. Rodrigo; Patrick J. Bradley; Vincent Vander Poorten; Asterios Triantafyllou; Jennifer L. Hunt; Primož Strojan; Alessandra Rinaldo; Missak Haigentz; Robert P. Takes; Vanni Mondin; Afshin Teymoortash; Lester D.R. Thompson; Alfio Ferlito

doi:10.1016/j.oraloncology.2015.04.005

Adenoid cystic carcinoma of the head and neck - An update

Andrés Coca-Pelaz, Juan P. Rodrigo, Patrick J. Bradley, Vincent Vander Poorten, Asterios Triantafyllou, Jennifer L. Hunt, Primož Strojan, Alessandra Rinaldo, Missak Haigentz, Robert P. Takes, Vanni Mondin, Afshin Teymoortash, Lester D.R. Thompson, Alfio Ferlito

Medicine

Research output: Contribution to journal › Review article › peer-review

342 Scopus citations

Abstract

This article provides an update on the current understanding of adenoid cystic carcinoma of the head and neck, including a review of its epidemiology, clinical behavior, pathology, molecular biology, diagnostic workup, treatment and prognosis. Adenoid cystic carcinoma is an uncommon salivary gland tumor that may arise in a wide variety of anatomical sites in the head and neck, often with an advanced stage at diagnosis. The clinical course is characterized by very late recurrences; consequently, clinical follow-up should extend at least >15 years. The optimal treatment is generally considered to be surgery with postoperative radiotherapy to optimize local disease control. Much effort has been invested into understanding the tumor's molecular biological processes, aiming to identify patients at high risk of recurrence, in hopes that they could benefit from other, still unproven treatment modalities such as chemotherapy or biological therapy.

Original language	English (US)
Pages (from-to)	652-661
Number of pages	10
Journal	Oral Oncology
Volume	51
Issue number	7
DOIs	https://doi.org/10.1016/j.oraloncology.2015.04.005
State	Published - Jul 1 2015

Keywords

Adenoid cystic carcinoma
Head and neck cancer
Molecular biology
Pathology
Prognosis
Salivary gland

ASJC Scopus subject areas

Oral Surgery
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.oraloncology.2015.04.005

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title = "Adenoid cystic carcinoma of the head and neck - An update",

abstract = "This article provides an update on the current understanding of adenoid cystic carcinoma of the head and neck, including a review of its epidemiology, clinical behavior, pathology, molecular biology, diagnostic workup, treatment and prognosis. Adenoid cystic carcinoma is an uncommon salivary gland tumor that may arise in a wide variety of anatomical sites in the head and neck, often with an advanced stage at diagnosis. The clinical course is characterized by very late recurrences; consequently, clinical follow-up should extend at least >15 years. The optimal treatment is generally considered to be surgery with postoperative radiotherapy to optimize local disease control. Much effort has been invested into understanding the tumor's molecular biological processes, aiming to identify patients at high risk of recurrence, in hopes that they could benefit from other, still unproven treatment modalities such as chemotherapy or biological therapy.",

keywords = "Adenoid cystic carcinoma, Head and neck cancer, Molecular biology, Pathology, Prognosis, Salivary gland",

author = "Andr{\'e}s Coca-Pelaz and Rodrigo, {Juan P.} and Bradley, {Patrick J.} and {Vander Poorten}, Vincent and Asterios Triantafyllou and Hunt, {Jennifer L.} and Primo{\v z} Strojan and Alessandra Rinaldo and Missak Haigentz and Takes, {Robert P.} and Vanni Mondin and Afshin Teymoortash and Thompson, {Lester D.R.} and Alfio Ferlito",

year = "2015",

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doi = "10.1016/j.oraloncology.2015.04.005",

language = "English (US)",

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T1 - Adenoid cystic carcinoma of the head and neck - An update

AU - Coca-Pelaz, Andrés

AU - Rodrigo, Juan P.

AU - Bradley, Patrick J.

AU - Vander Poorten, Vincent

AU - Triantafyllou, Asterios

AU - Hunt, Jennifer L.

AU - Strojan, Primož

AU - Rinaldo, Alessandra

AU - Haigentz, Missak

AU - Takes, Robert P.

AU - Mondin, Vanni

AU - Teymoortash, Afshin

AU - Thompson, Lester D.R.

AU - Ferlito, Alfio

PY - 2015/7/1

Y1 - 2015/7/1

N2 - This article provides an update on the current understanding of adenoid cystic carcinoma of the head and neck, including a review of its epidemiology, clinical behavior, pathology, molecular biology, diagnostic workup, treatment and prognosis. Adenoid cystic carcinoma is an uncommon salivary gland tumor that may arise in a wide variety of anatomical sites in the head and neck, often with an advanced stage at diagnosis. The clinical course is characterized by very late recurrences; consequently, clinical follow-up should extend at least >15 years. The optimal treatment is generally considered to be surgery with postoperative radiotherapy to optimize local disease control. Much effort has been invested into understanding the tumor's molecular biological processes, aiming to identify patients at high risk of recurrence, in hopes that they could benefit from other, still unproven treatment modalities such as chemotherapy or biological therapy.

AB - This article provides an update on the current understanding of adenoid cystic carcinoma of the head and neck, including a review of its epidemiology, clinical behavior, pathology, molecular biology, diagnostic workup, treatment and prognosis. Adenoid cystic carcinoma is an uncommon salivary gland tumor that may arise in a wide variety of anatomical sites in the head and neck, often with an advanced stage at diagnosis. The clinical course is characterized by very late recurrences; consequently, clinical follow-up should extend at least >15 years. The optimal treatment is generally considered to be surgery with postoperative radiotherapy to optimize local disease control. Much effort has been invested into understanding the tumor's molecular biological processes, aiming to identify patients at high risk of recurrence, in hopes that they could benefit from other, still unproven treatment modalities such as chemotherapy or biological therapy.

KW - Adenoid cystic carcinoma

KW - Head and neck cancer

KW - Molecular biology

KW - Pathology

KW - Prognosis

KW - Salivary gland

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JO - Oral Oncology

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IS - 7

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Adenoid cystic carcinoma of the head and neck - An update

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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