TY - JOUR
T1 - Additive value of nicorandil on ATP for further inducing hyperemia in patients with an intermediate coronary artery stenosis
AU - Kobayashi, Yuhei
AU - Okura, Hiroyuki
AU - Neishi, Yoji
AU - Higa, Tomitaka
AU - Kobayashi, Yukari
AU - Uemura, Shiro
AU - Yoshida, Kiyoshi
N1 - Publisher Copyright:
© 2017 Wolters Kluwer Health, Inc.
PY - 2017
Y1 - 2017
N2 - Background The induction of hyperemia is of importance to precisely assess the functional significance of coronary artery lesions with fractional flow reserve (FFR). Adenosine or ATP alone is used widely in this setting; however, little is known about the additive value of nicorandil, which acts as a nitrate and a K + -ATP channel opener, to induce further hyperemia. Patients and methods A total of 183 intermediate native coronary artery lesions from 112 patients were prospectively enrolled into this study. FFR was measured using a coronary pressure wire during an intravenous ATP infusion alone (150 mcg/kg/min) (FFR ATP) and repeated after an adjunctive intracoronary nicorandil injection (2.0 mg) (FFR ATP+Nico). Results Physiologic measurements were completed without any severe adverse effects from ATP and nicorandil in all patients. FFR ATP and FFR ATP+Nico had a strong linear correlation (R 2 =0.79, P<0.001). The FFR value became significantly lower with an adjunctive intracoronary nicorandil injection compared with ATP alone [FFR ATP vs. FFR ATP+Nico, 0.87 (interquartile range: 0.81-0.92) vs. 0.85 (0.79-0.90), P<0.001]. A total of 18 lesions out of 183 (9.8%) were reclassified after a nicorandil injection (12 from FFR>0.80 to ≤0.80 vs. six from FFR≤0.80 to >0.80, P=0.26). The adjunctive effect of nicorandil was accentuated with each increment of FFR ATP strata (per 0.05 increase, P for trend<0.001), but with minimal effect around the borderline FFR zone. Conclusion An adjunctive intracoronary nicorandil injection is safe, but appears to have little effect in inducing further hyperemia. Therefore, its effect on the clinical scenario is limited.
AB - Background The induction of hyperemia is of importance to precisely assess the functional significance of coronary artery lesions with fractional flow reserve (FFR). Adenosine or ATP alone is used widely in this setting; however, little is known about the additive value of nicorandil, which acts as a nitrate and a K + -ATP channel opener, to induce further hyperemia. Patients and methods A total of 183 intermediate native coronary artery lesions from 112 patients were prospectively enrolled into this study. FFR was measured using a coronary pressure wire during an intravenous ATP infusion alone (150 mcg/kg/min) (FFR ATP) and repeated after an adjunctive intracoronary nicorandil injection (2.0 mg) (FFR ATP+Nico). Results Physiologic measurements were completed without any severe adverse effects from ATP and nicorandil in all patients. FFR ATP and FFR ATP+Nico had a strong linear correlation (R 2 =0.79, P<0.001). The FFR value became significantly lower with an adjunctive intracoronary nicorandil injection compared with ATP alone [FFR ATP vs. FFR ATP+Nico, 0.87 (interquartile range: 0.81-0.92) vs. 0.85 (0.79-0.90), P<0.001]. A total of 18 lesions out of 183 (9.8%) were reclassified after a nicorandil injection (12 from FFR>0.80 to ≤0.80 vs. six from FFR≤0.80 to >0.80, P=0.26). The adjunctive effect of nicorandil was accentuated with each increment of FFR ATP strata (per 0.05 increase, P for trend<0.001), but with minimal effect around the borderline FFR zone. Conclusion An adjunctive intracoronary nicorandil injection is safe, but appears to have little effect in inducing further hyperemia. Therefore, its effect on the clinical scenario is limited.
KW - fractional flow reserve
KW - hyperemia
KW - nicorandil
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U2 - 10.1097/MCA.0000000000000433
DO - 10.1097/MCA.0000000000000433
M3 - Article
C2 - 27611876
AN - SCOPUS:84986222179
SN - 0954-6928
VL - 28
SP - 104
EP - 109
JO - Coronary Artery Disease
JF - Coronary Artery Disease
IS - 2
ER -