Acute Corneal Endothelial Graft Rejection With Coinciding COVID-19 Infection

Sierra X. Jin, Viral V. Juthani

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Purpose: To report a case of acute corneal endothelial graft rejection with the concurrent onset of coronavirus disease 2019 (COVID-19) symptoms. Methods: Case report. Results: A 31-year-old African American woman with a history of asthma, sleep apnea, obesity (body mass index of 40), and bilateral keratoconus was noted to have acute corneal endothelial graft rejection 3 months after uncomplicated penetrating keratoplasty of the left eye. The patient developed dysgeusia and subjective fever on the same day as ocular discomfort, and she was subsequently diagnosed with COVID-19 with only these 2 classic symptoms of the viral infection. Conclusions: Severe acute respiratory syndrome coronavirus 2 is known to cause conjunctivitis and has demonstrated transmissibility through ocular secretions. Acute immune and inflammatory dysregulations have been seen in cases of COVID-19 through various mechanisms. COVID-19 infection may potentially compromise ocular immune privilege contributing to acute corneal graft rejection.

Original languageEnglish (US)
Pages (from-to)123-124
Number of pages2
Issue number1
StatePublished - Jan 1 2021


  • COVID-19
  • SARS-CoV-2
  • acute graft rejection
  • corneal graft rejection
  • coronavirus

ASJC Scopus subject areas

  • Ophthalmology


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