Actions of toxins on cerebral metabolism at the cellular level

U. Sonnewald; T. Syversen; A. Schousboe; H. Waagepetersen; M. Aschner

doi:10.1007/978-0-387-30411-3_21

Actions of toxins on cerebral metabolism at the cellular level

U. Sonnewald, T. Syversen, A. Schousboe, H. Waagepetersen, M. Aschner

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Neurotoxins can cause disease by interfering with brain metabolism. The present chapter describes metabolic effects of methionine sulfoximine (MSO), 3-nitropropionic acid (3-NPA), aminooxyacetic acid (AOAA), and methylmercury (MeHg) on astrocytes and neurons in culture. Often toxins act in a cell-specific manner, which is the case for MSO acting mostly on astrocytes, whereas MeHg, AOAA, and 3-NPA exert their effects mostly on neurons. In the case of MeHg this effect is possibly mediated via astrocytes. The adverse cellular effects of these toxic compounds can be used for probing metabolism and creating animal models of disease, thus providing means for a better understanding of the etiology of neurological disorders, as well as for testing the effectiveness of potential treatment modalities.

Original language	English (US)
Title of host publication	Handbook of Neurochemistry and Molecular Neurobiology
Subtitle of host publication	Brain Energetics. Integration of Molecular and Cellular Processes
Publisher	Springer US
Pages	569-585
Number of pages	17
ISBN (Print)	9780387303468
DOIs	https://doi.org/10.1007/978-0-387-30411-3_21
State	Published - Dec 1 2007
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)

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10.1007/978-0-387-30411-3_21

Cite this

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abstract = "Neurotoxins can cause disease by interfering with brain metabolism. The present chapter describes metabolic effects of methionine sulfoximine (MSO), 3-nitropropionic acid (3-NPA), aminooxyacetic acid (AOAA), and methylmercury (MeHg) on astrocytes and neurons in culture. Often toxins act in a cell-specific manner, which is the case for MSO acting mostly on astrocytes, whereas MeHg, AOAA, and 3-NPA exert their effects mostly on neurons. In the case of MeHg this effect is possibly mediated via astrocytes. The adverse cellular effects of these toxic compounds can be used for probing metabolism and creating animal models of disease, thus providing means for a better understanding of the etiology of neurological disorders, as well as for testing the effectiveness of potential treatment modalities.",

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AU - Waagepetersen, H.

AU - Aschner, M.

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AB - Neurotoxins can cause disease by interfering with brain metabolism. The present chapter describes metabolic effects of methionine sulfoximine (MSO), 3-nitropropionic acid (3-NPA), aminooxyacetic acid (AOAA), and methylmercury (MeHg) on astrocytes and neurons in culture. Often toxins act in a cell-specific manner, which is the case for MSO acting mostly on astrocytes, whereas MeHg, AOAA, and 3-NPA exert their effects mostly on neurons. In the case of MeHg this effect is possibly mediated via astrocytes. The adverse cellular effects of these toxic compounds can be used for probing metabolism and creating animal models of disease, thus providing means for a better understanding of the etiology of neurological disorders, as well as for testing the effectiveness of potential treatment modalities.

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Actions of toxins on cerebral metabolism at the cellular level

Abstract

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