Neurotoxins can cause disease by interfering with brain metabolism. The present chapter describes metabolic effects of methionine sulfoximine (MSO), 3-nitropropionic acid (3-NPA), aminooxyacetic acid (AOAA), and methylmercury (MeHg) on astrocytes and neurons in culture. Often toxins act in a cell-specific manner, which is the case for MSO acting mostly on astrocytes, whereas MeHg, AOAA, and 3-NPA exert their effects mostly on neurons. In the case of MeHg this effect is possibly mediated via astrocytes. The adverse cellular effects of these toxic compounds can be used for probing metabolism and creating animal models of disease, thus providing means for a better understanding of the etiology of neurological disorders, as well as for testing the effectiveness of potential treatment modalities.
|Original language||English (US)|
|Title of host publication||Handbook of Neurochemistry and Molecular Neurobiology|
|Subtitle of host publication||Brain Energetics. Integration of Molecular and Cellular Processes|
|Number of pages||17|
|State||Published - Dec 1 2007|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)