Actin is oxidized during myocardial ischemia

Saul R. Powell; Ellen M. Gurzenda; Sayed Emal Wahezi

doi:10.1016/S0891-5849(01)00514-7

Actin is oxidized during myocardial ischemia

Saul R. Powell
, Ellen M. Gurzenda
, Sayed Emal Wahezi

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Exposure of isolated rat hearts to 30 min global ischemia followed by 60 min reperfusion resulted in a significant 80% increase (p <. 05) in actin content of carbonyl groups, which was associated with significant depression (p <. 05) of postischemic contractile function. This result supports the hypothesis that one mechanism of postischemic contractile dysfunction may be oxidation of contractile proteins.

Original language	English (US)
Pages (from-to)	1171-1176
Number of pages	6
Journal	Free Radical Biology and Medicine
Volume	30
Issue number	10
DOIs	https://doi.org/10.1016/S0891-5849(01)00514-7
State	Published - May 15 2001
Externally published	Yes

Keywords

Actin
Free radicals
Myocardial ischemia
Protein carbonyls
Protein oxidation

ASJC Scopus subject areas

Biochemistry
Physiology (medical)

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10.1016/S0891-5849(01)00514-7

Cite this

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title = "Actin is oxidized during myocardial ischemia",

abstract = "Exposure of isolated rat hearts to 30 min global ischemia followed by 60 min reperfusion resulted in a significant 80\% increase (p <. 05) in actin content of carbonyl groups, which was associated with significant depression (p <. 05) of postischemic contractile function. This result supports the hypothesis that one mechanism of postischemic contractile dysfunction may be oxidation of contractile proteins.",

keywords = "Actin, Free radicals, Myocardial ischemia, Protein carbonyls, Protein oxidation",

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T1 - Actin is oxidized during myocardial ischemia

AU - Powell, Saul R.

AU - Gurzenda, Ellen M.

AU - Wahezi, Sayed Emal

PY - 2001/5/15

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N2 - Exposure of isolated rat hearts to 30 min global ischemia followed by 60 min reperfusion resulted in a significant 80% increase (p <. 05) in actin content of carbonyl groups, which was associated with significant depression (p <. 05) of postischemic contractile function. This result supports the hypothesis that one mechanism of postischemic contractile dysfunction may be oxidation of contractile proteins.

AB - Exposure of isolated rat hearts to 30 min global ischemia followed by 60 min reperfusion resulted in a significant 80% increase (p <. 05) in actin content of carbonyl groups, which was associated with significant depression (p <. 05) of postischemic contractile function. This result supports the hypothesis that one mechanism of postischemic contractile dysfunction may be oxidation of contractile proteins.

KW - Actin

KW - Free radicals

KW - Myocardial ischemia

KW - Protein carbonyls

KW - Protein oxidation

UR - https://www.scopus.com/pages/publications/0035873939

UR - https://www.scopus.com/pages/publications/0035873939#tab=citedBy

U2 - 10.1016/S0891-5849(01)00514-7

DO - 10.1016/S0891-5849(01)00514-7

M3 - Article

C2 - 11369508

AN - SCOPUS:0035873939

SN - 0891-5849

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JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

IS - 10

ER -

Actin is oxidized during myocardial ischemia

Abstract

Keywords

ASJC Scopus subject areas

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