In the rat, ACTH effected a transient rise in the level of plasma renin. Pretreatment with glucocorticoids completely inhibited the ACTH-induced renin rise. After adrenalectomy or inhibition of steroidogenesis by aminoglutethimide. ACTH produced a sustained rise in plasma renin level. Thus in the rat, ACTH has a direct effect on the juxtaglomerular apparatus causing a rise in plasma renin activity and glucocorticoids have an opposing action.
|Number of pages
|Proceedings of the Society for Experimental Biology and Medicine
|Published - Jun 1969
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology