ACR Appropriateness Criteria® Cranial Neuropathy: 2022 Update

Expert Panel on Neurological Imaging:

Research output: Contribution to journalArticlepeer-review


Cranial neuropathy can result from pathology affecting the nerve fibers at any point and requires imaging of the entire course of the nerve from its nucleus to the end organ in order to identify a cause. MRI with and without intravenous contrast is often the modality of choice with CT playing a complementary role. The ACR Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision process support the systematic analysis of the medical literature from peer-reviewed journals. Established methodology principles such as Grading of Recommendations Assessment, Development, and Evaluation or GRADE are adapted to evaluate the evidence. The RAND/UCLA Appropriateness Method User Manual provides the methodology to determine the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances in which peer-reviewed literature is lacking or equivocal, experts may be the primary evidentiary source available to formulate a recommendation.

Original languageEnglish (US)
Pages (from-to)S266-S303
JournalJournal of the American College of Radiology
Issue number11
StatePublished - Nov 2022
Externally publishedYes


  • AUC
  • Appropriate Use Criteria
  • Appropriateness Criteria
  • Cranial nerves
  • Cranial neuropathy
  • Hemifacial spasm
  • Perineural tumor spread
  • Trigeminal neuralgia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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