ACE2 as therapy for glomerular disease: the devil is in the detail

Michael J. Ross; Masaomi Nangaku

doi:10.1016/j.kint.2017.04.001

ACE2 as therapy for glomerular disease: the devil is in the detail

Michael J. Ross, Masaomi Nangaku

Medicine

Research output: Contribution to journal › Comment/debate › peer-review

13 Scopus citations

Abstract

Angiotensin-converting enzyme 2 cleaves angiotensin (Ang) II to Ang(1-7), which antagonizes the deleterious effects of Ang II. In this issue, 2 groups administered angiotensin-converting enzyme 2 in murine models of kidney disease. Angiotensin-converting enzyme 2 did not improve glomerular injury in 2 models of mild diabetic nephropathy but was partially protective in an Alport syndrome model. These discrepant findings may be explained by the inability of angiotensin-converting enzyme 2 to reach the urinary space in the absence of severe proteinuria.

Original language	English (US)
Pages (from-to)	1269-1271
Number of pages	3
Journal	Kidney international
Volume	91
Issue number	6
DOIs	https://doi.org/10.1016/j.kint.2017.04.001
State	Published - Jun 2017

ASJC Scopus subject areas

Nephrology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.kint.2017.04.001

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title = "ACE2 as therapy for glomerular disease: the devil is in the detail",

abstract = "Angiotensin-converting enzyme 2 cleaves angiotensin (Ang) II to Ang(1-7), which antagonizes the deleterious effects of Ang II. In this issue, 2 groups administered angiotensin-converting enzyme 2 in murine models of kidney disease. Angiotensin-converting enzyme 2 did not improve glomerular injury in 2 models of mild diabetic nephropathy but was partially protective in an Alport syndrome model. These discrepant findings may be explained by the inability of angiotensin-converting enzyme 2 to reach the urinary space in the absence of severe proteinuria.",

author = "Ross, {Michael J.} and Masaomi Nangaku",

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doi = "10.1016/j.kint.2017.04.001",

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AU - Nangaku, Masaomi

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AB - Angiotensin-converting enzyme 2 cleaves angiotensin (Ang) II to Ang(1-7), which antagonizes the deleterious effects of Ang II. In this issue, 2 groups administered angiotensin-converting enzyme 2 in murine models of kidney disease. Angiotensin-converting enzyme 2 did not improve glomerular injury in 2 models of mild diabetic nephropathy but was partially protective in an Alport syndrome model. These discrepant findings may be explained by the inability of angiotensin-converting enzyme 2 to reach the urinary space in the absence of severe proteinuria.

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ACE2 as therapy for glomerular disease: the devil is in the detail

Abstract

ASJC Scopus subject areas

UN SDGs

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