Acanthamoeba, Naegleria, and Balamuthia in Transplant Patients: An Emerging Threat

Yoram A. Puius; Margaret L. Aldrich; Jennifer R. Cope

doi:10.1007/978-3-030-25869-6_58

Acanthamoeba, Naegleria, and Balamuthia in Transplant Patients: An Emerging Threat

Yoram A. Puius, Margaret L. Aldrich, Jennifer R. Cope

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Free-living amoebae (FLA) are ubiquitous in the environment. Although they rarely cause infection in humans, when they do so, the infection is often severe and diagnosed late. The three most clinically relevant genera of FLA are Acanthamoeba spp., Naegleria fowleri, and Balamuthia mandrillaris. An increasing body of literature points to these organisms as potential disease-causing agents in immunocompromised and transplant patients, particularly with regard to donor-derived infections. This chapter will review the salient features, diagnostic modalities, and therapeutic recommendations of these infections in transplant patients.

Original language	English (US)
Title of host publication	Emerging Transplant Infections
Subtitle of host publication	Clinical Challenges and Implications
Publisher	Springer International Publishing
Pages	1451-1472
Number of pages	22
ISBN (Electronic)	9783030258696
ISBN (Print)	9783030258689
DOIs	https://doi.org/10.1007/978-3-030-25869-6_58
State	Published - Jan 1 2021

Keywords

Acanthamoeba
Balamuthia mandrillaris
Donor-derived infection
Granulomatous amebic encephalitis
Naegleria fowleri
Primary amebic meningoencephalitis

ASJC Scopus subject areas

General Medicine

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10.1007/978-3-030-25869-6_58

Cite this

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title = "Acanthamoeba, Naegleria, and Balamuthia in Transplant Patients: An Emerging Threat",

abstract = "Free-living amoebae (FLA) are ubiquitous in the environment. Although they rarely cause infection in humans, when they do so, the infection is often severe and diagnosed late. The three most clinically relevant genera of FLA are Acanthamoeba spp., Naegleria fowleri, and Balamuthia mandrillaris. An increasing body of literature points to these organisms as potential disease-causing agents in immunocompromised and transplant patients, particularly with regard to donor-derived infections. This chapter will review the salient features, diagnostic modalities, and therapeutic recommendations of these infections in transplant patients.",

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AU - Aldrich, Margaret L.

AU - Cope, Jennifer R.

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AB - Free-living amoebae (FLA) are ubiquitous in the environment. Although they rarely cause infection in humans, when they do so, the infection is often severe and diagnosed late. The three most clinically relevant genera of FLA are Acanthamoeba spp., Naegleria fowleri, and Balamuthia mandrillaris. An increasing body of literature points to these organisms as potential disease-causing agents in immunocompromised and transplant patients, particularly with regard to donor-derived infections. This chapter will review the salient features, diagnostic modalities, and therapeutic recommendations of these infections in transplant patients.

KW - Acanthamoeba

KW - Balamuthia mandrillaris

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Acanthamoeba, Naegleria, and Balamuthia in Transplant Patients: An Emerging Threat

Abstract

Keywords

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