ABO blood type association with SARS-CoV-2 infection mortality: A single-center population in New York City

James Szymanski, Laurel Mohrmann, Jamal Carter, Randin Nelson, Sweta Chekuri, Andrei Assa, Brian Spund, Morayma Reyes-Gil, Joan Uehlinger, Sarah Baron, Monika Paroder

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a variable clinical course with significant mortality. Early reports suggested higher rates of SARS-CoV-2 infection in patients with type A blood and enrichment of type A individuals among COVID-19 mortalities. Study Design and Methods: The study includes all patients hospitalized or with an emergency department (ED) visit who were tested for SARS-CoV-2 between March 10, 2020 and June 8, 2020 and had a positive test result by nucleic acid test (NAT) performed on a nasopharyngeal swab specimen. A total of 4968 patients met the study inclusion criteria, with a subsequent 23.1% (n = 1146/4968) all-cause mortality rate in the study cohort. To estimate overall risk by ABO type and account for the competing risks of in-hospital mortality and discharge, we calculated the cumulative incidence function (CIF) for each event. Cause-specific hazard ratios (csHRs) for in-hospital mortality and discharge were analyzed using multivariable Cox proportional hazards models. Results: Type A blood was associated with the increased cause-specific hazard of death among COVID-19 patients compared to type O (HR = 1.17, 1.02–1.33, p =.02) and type B (HR = 1.32,1.10–1.58, p =.003). Conclusions: Our study shows that ABO histo-blood group type is associated with the risk of in-hospital death in COVID-19 patients, warranting additional inquiry. Elucidating the mechanism behind this association may reveal insights into the susceptibility and/or immunity to SARS-CoV-2.

Original languageEnglish (US)
Pages (from-to)1064-1070
Number of pages7
Issue number4
StatePublished - Apr 2021


  • ABO
  • SARS-CoV-2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology


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