A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus

Siradanahalli C. Guru; Sunita K. Agarwal; Pachiappan Manickam; Shodimu Emmanuel Olufemi; Judy S. Crabtree; Jane M. Weisemann; Mary Beth Kester; Young S. Kim; Yingping Wang; Michael R. Emmert-Buck; Lance A. Liotta; Allen M. Spiegel; Mark S. Boguski; Bruce A. Roe; Francis S. Collins; Stephen J. Marx; Lee Burns; Settara C. Chandrasekharappa

doi:10.1101/gr.7.7.725

A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus

Siradanahalli C. Guru, Sunita K. Agarwal, Pachiappan Manickam, Shodimu Emmanuel Olufemi, Judy S. Crabtree, Jane M. Weisemann, Mary Beth Kester, Young S. Kim, Yingping Wang, Michael R. Emmert-Buck, Lance A. Liotta, Allen M. Spiegel, Mark S. Boguski, Bruce A. Roe, Francis S. Collins, Stephen J. Marx, Lee Burns, Settara C. Chandrasekharappa

Research output: Contribution to journal › Article › peer-review

113 Scopus citations

Abstract

Multiple endocrine neoplasia type 1 (MEN 1) is an inherited cancer syndrome in which affected individuals develop multiple parathyroid, enteropancreatic, and pituitary tumors. The locus for MEN1 is tightly linked to the marker PYGM on chromosome 11q13, and linkage analysis places the MEN1 gene within a 2-Mb interval flanked by the markers D11S1883 and D11S449. Loss of heterozygosity studies in MEN 1 and sporadic tumors suggest that the MEN1 gene encodes a tumor suppressor and have helped to narrow the location of the gene to a 600-kb interval between PYGM and D11S449. Focusing on this smaller MEN1 interval, we have identified and mapped 12 transcripts to this 600-kb region. A precise ordered map of 33 transcripts, including 12 genes known to map to this region, was generated for the 2.8-Mb D11S480-D11S913 interval. Fifteen candidate genes (of which 10 were examined exhaustively) were evaluated by Southern blot and/or dideoxy fingerprinting analysis to identify the gene harboring disease-causing mutations.

Original language	English (US)
Pages (from-to)	725-735
Number of pages	11
Journal	Genome research
Volume	7
Issue number	7
DOIs	https://doi.org/10.1101/gr.7.7.725
State	Published - Jul 1997
Externally published	Yes

ASJC Scopus subject areas

Genetics
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1101/gr.7.7.725

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Guru, S. C., Agarwal, S. K., Manickam, P., Olufemi, S. E., Crabtree, J. S., Weisemann, J. M., Kester, M. B., Kim, Y. S., Wang, Y., Emmert-Buck, M. R., Liotta, L. A., Spiegel, A. M., Boguski, M. S., Roe, B. A., Collins, F. S., Marx, S. J., Burns, L., & Chandrasekharappa, S. C. (1997). A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. Genome research, 7(7), 725-735. https://doi.org/10.1101/gr.7.7.725

Guru, SC, Agarwal, SK, Manickam, P, Olufemi, SE, Crabtree, JS, Weisemann, JM, Kester, MB, Kim, YS, Wang, Y, Emmert-Buck, MR, Liotta, LA, Spiegel, AM, Boguski, MS, Roe, BA, Collins, FS, Marx, SJ, Burns, L & Chandrasekharappa, SC 1997, 'A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus', Genome research, vol. 7, no. 7, pp. 725-735. https://doi.org/10.1101/gr.7.7.725

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title = "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus",

abstract = "Multiple endocrine neoplasia type 1 (MEN 1) is an inherited cancer syndrome in which affected individuals develop multiple parathyroid, enteropancreatic, and pituitary tumors. The locus for MEN1 is tightly linked to the marker PYGM on chromosome 11q13, and linkage analysis places the MEN1 gene within a 2-Mb interval flanked by the markers D11S1883 and D11S449. Loss of heterozygosity studies in MEN 1 and sporadic tumors suggest that the MEN1 gene encodes a tumor suppressor and have helped to narrow the location of the gene to a 600-kb interval between PYGM and D11S449. Focusing on this smaller MEN1 interval, we have identified and mapped 12 transcripts to this 600-kb region. A precise ordered map of 33 transcripts, including 12 genes known to map to this region, was generated for the 2.8-Mb D11S480-D11S913 interval. Fifteen candidate genes (of which 10 were examined exhaustively) were evaluated by Southern blot and/or dideoxy fingerprinting analysis to identify the gene harboring disease-causing mutations.",

author = "Guru, {Siradanahalli C.} and Agarwal, {Sunita K.} and Pachiappan Manickam and Olufemi, {Shodimu Emmanuel} and Crabtree, {Judy S.} and Weisemann, {Jane M.} and Kester, {Mary Beth} and Kim, {Young S.} and Yingping Wang and Emmert-Buck, {Michael R.} and Liotta, {Lance A.} and Spiegel, {Allen M.} and Boguski, {Mark S.} and Roe, {Bruce A.} and Collins, {Francis S.} and Marx, {Stephen J.} and Lee Burns and Chandrasekharappa, {Settara C.}",

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AU - Emmert-Buck, Michael R.

AU - Liotta, Lance A.

AU - Spiegel, Allen M.

AU - Boguski, Mark S.

AU - Roe, Bruce A.

AU - Collins, Francis S.

AU - Marx, Stephen J.

AU - Burns, Lee

AU - Chandrasekharappa, Settara C.

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AB - Multiple endocrine neoplasia type 1 (MEN 1) is an inherited cancer syndrome in which affected individuals develop multiple parathyroid, enteropancreatic, and pituitary tumors. The locus for MEN1 is tightly linked to the marker PYGM on chromosome 11q13, and linkage analysis places the MEN1 gene within a 2-Mb interval flanked by the markers D11S1883 and D11S449. Loss of heterozygosity studies in MEN 1 and sporadic tumors suggest that the MEN1 gene encodes a tumor suppressor and have helped to narrow the location of the gene to a 600-kb interval between PYGM and D11S449. Focusing on this smaller MEN1 interval, we have identified and mapped 12 transcripts to this 600-kb region. A precise ordered map of 33 transcripts, including 12 genes known to map to this region, was generated for the 2.8-Mb D11S480-D11S913 interval. Fifteen candidate genes (of which 10 were examined exhaustively) were evaluated by Southern blot and/or dideoxy fingerprinting analysis to identify the gene harboring disease-causing mutations.

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A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus

Abstract

ASJC Scopus subject areas

UN SDGs

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