A Single Dominant Gene Can Account for Eye Tracking Dysfunctions and Schizophrenia in Offspring of Discordant Twins

Philip S. Holzman; Einar Kringlen; Steven Matthysse; Steven D. Flanagan; Richard B. Lipton; Gunnar Cramer; Smadar Levin; Kenneth Lange; Deborah L. Levy

doi:10.1001/archpsyc.1988.01800310049006

A Single Dominant Gene Can Account for Eye Tracking Dysfunctions and Schizophrenia in Offspring of Discordant Twins

Philip S. Holzman, Einar Kringlen, Steven Matthysse, Steven D. Flanagan, Richard B. Lipton, Gunnar Cramer, Smadar Levin, Kenneth Lange, Deborah L. Levy

Neurology

Research output: Contribution to journal › Article › peer-review

204 Scopus citations

Abstract

Eye movement dysfunctions (EMDs), detectable during smooth pursuit, occur in a majority of schizophrenics and in 45% of their first-degree relatives. Previous data suggest that they represent a biologic marker for schizophrenia. To determine the mode of transmission of the schizophrenia-EMD complex, the eye movements of offspring of monozygotic and dizygotic twins were recorded. One group of twins was discordant for schizophrenia; the other group for manic depression or reactive psychosis. The data suggest that EMDs and at least some schizophrenias can be considered expressions of a single underlying trait that is transmitted by an autosomal dominant gene.

Original language	English (US)
Pages (from-to)	641-647
Number of pages	7
Journal	Archives of General Psychiatry
Volume	45
Issue number	7
DOIs	https://doi.org/10.1001/archpsyc.1988.01800310049006
State	Published - Jul 1988

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Psychiatry and Mental health

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1001/archpsyc.1988.01800310049006

Cite this

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abstract = "Eye movement dysfunctions (EMDs), detectable during smooth pursuit, occur in a majority of schizophrenics and in 45% of their first-degree relatives. Previous data suggest that they represent a biologic marker for schizophrenia. To determine the mode of transmission of the schizophrenia-EMD complex, the eye movements of offspring of monozygotic and dizygotic twins were recorded. One group of twins was discordant for schizophrenia; the other group for manic depression or reactive psychosis. The data suggest that EMDs and at least some schizophrenias can be considered expressions of a single underlying trait that is transmitted by an autosomal dominant gene.",

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AU - Holzman, Philip S.

AU - Kringlen, Einar

AU - Matthysse, Steven

AU - Flanagan, Steven D.

AU - Lipton, Richard B.

AU - Cramer, Gunnar

AU - Levin, Smadar

AU - Lange, Kenneth

AU - Levy, Deborah L.

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AB - Eye movement dysfunctions (EMDs), detectable during smooth pursuit, occur in a majority of schizophrenics and in 45% of their first-degree relatives. Previous data suggest that they represent a biologic marker for schizophrenia. To determine the mode of transmission of the schizophrenia-EMD complex, the eye movements of offspring of monozygotic and dizygotic twins were recorded. One group of twins was discordant for schizophrenia; the other group for manic depression or reactive psychosis. The data suggest that EMDs and at least some schizophrenias can be considered expressions of a single underlying trait that is transmitted by an autosomal dominant gene.

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A Single Dominant Gene Can Account for Eye Tracking Dysfunctions and Schizophrenia in Offspring of Discordant Twins

Abstract

ASJC Scopus subject areas

UN SDGs

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