@article{0651168d41b144f5a7b6c4857f50d896,
title = "A rapid test for the detection of human immunodeficiency virus antibodies in cord blood",
abstract = "A commercially available rapid test (HIVCHEK) was compared with an enzyme-linked immunosorbent assay (ELISA) for identifying human immunodeficiency virus type 1 in the serum of newborn infants. Of 1309 cord blood samples tested, the HIVCHEK test detected all the true-positive samples detected by ELISA. Of the 35 samples with positive ELISA results, six had negative results on Western blot; only 1 of the 20 samples with positive HIVCHEK results had negative results on Western blot. Thus the HIVCHEK test can be used to facilitate the rapid identification of HIV-1 in the serum of newborn infants.",
author = "Suarez, {Miguel A.} and Betty Blanco and Brion, {Luc P.} and Marjorie Schulman and Calvelli, {Theresa A.} and Joan Youchah and Yair Devash and Arye Rubinstein and Harris Goldstein",
note = "Funding Information: Various studies have indicated that the proportion of pregnancies of seropositive women that result in offspring infected with human immunodeficiency virus type 1 ranges from 13% to 39%. 13 Although the transplacental transport of maternal antibodies complicates the diagnosis of con. genital HIV-I infection, 1 the earlier the infants at risk for congenital HIV-1 infection are identified, the sooner they can be targeted for diagnosis, follow-up, and therapy. However, because the commonly used enzyme-linked immunosorbent and Western blot assays take from several hours to days to perform and must be done in specialized laboratories, they cannot easily be used to identify HIV-1 seropositivity in newborn infants before their discharge from the hospital. We evaluated assessments of cord blood samples for reactivity With HIV-1 by a new, easily performed colorimetric test that detects IgG antibodies in Supported by National Institute of Allergy and Infectious Diseases grants AI27533, AI27741, and AI20671. Submitted for publication Feb. 1, 1993; accepted March 24, 1993. Reprint requests: Harris Goldstein, MD, Albert Einstein College of Medicine, Chanin Building, Room 626, 1300 Morris Park Ave., Bronx, NY 10461. Copyright 9 1993 by Mosby-Year Book, Inc. 0022-3476/93/$1.00 + .10 9/22/47407 about 10 minutes, and then compared the results with those obtained by currently used ELISA and Western blot assays.",
year = "1993",
month = aug,
doi = "10.1016/S0022-3476(05)81698-1",
language = "English (US)",
volume = "123",
pages = "259--261",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "2",
}
