Abstract
The Caenorhabditis elegans excretory cell extends tubular processes, called canals, along the basolateral surface of the epidermis. Mutations in the exc-5 gene cause tubulocystic defects in this canal. Ultrastructural analysis suggests that exc-5 is required for the proper placement of cytoskeletal elements at the apical epithelial surface. exc-5 encodes a protein homologous to guanine nucleotide exchange factors and contains motif architecture similar to that of FGD1, which is responsible for faciogenital dysplasia. exc-5 interacts genetically with mig-2, which encodes Rho GTPase. These results suggest that EXC-5 controls the structural organization of the excretory canal by regulating Rho family GTPase activities.
Original language | English (US) |
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Pages (from-to) | 530-535 |
Number of pages | 6 |
Journal | EMBO Reports |
Volume | 2 |
Issue number | 6 |
DOIs | |
State | Published - 2001 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Genetics