A PR-1-like protein of Fusarium oxysporum functions in virulence on mammalian hosts

Rafael C. Prados-Rosales, Raquel Roldán-Rodríguez, Carolina Serena, Manuel S. López-Berges, Josep Guarro, Álvaro Martínez-del-Pozo, Antonio Di Pietro

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


The pathogenesis-related PR-1-like protein family comprises secreted proteins from the animal, plant, and fungal kingdoms whose biological function remains poorly understood. Here we have characterized a PR-1-like protein, Fpr1, from Fusarium oxysporum, an ubiquitous fungal pathogen that causes vascular wilt disease on a wide range of plant species and can produce life-threatening infections in immunocompromised humans. Fpr1 is secreted and proteolytically processed by the fungus. The fpr1 gene is required for virulence in a disseminated immunodepressed mouse model, and its function depends on the integrity of the proposed active site of PR-1-like proteins. Fpr1 belongs to a gene family that has expanded in plant pathogenic Sordariomycetes. These results suggest that secreted PR-1-like proteins play important roles in fungal pathogenicity.

Original languageEnglish (US)
Pages (from-to)21970-21979
Number of pages10
JournalJournal of Biological Chemistry
Issue number26
StatePublished - Jun 22 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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