A porcine model of prolonged closed chest venovenous extracorporeal membrane oxygenation

Giles J. Peek; Richard Scott; Hilliary M. Killer; Martin A. Jarvis; Shyam Kolvekar; Derek Forbes; Richard K. Firmin

doi:10.1097/00002480-199909000-00023

A porcine model of prolonged closed chest venovenous extracorporeal membrane oxygenation

Giles J. Peek, Richard Scott, Hilliary M. Killer, Martin A. Jarvis, Shyam Kolvekar, Derek Forbes, Richard K. Firmin

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The sheep has been the standard laboratory animal for extracorporeal membrane oxygenation (ECMO) research for many years and has proven to be an invaluable and reliable model. However the coagulation system of the sheep is significantly different from humans. These differences make it difficult to investigate the coagulative and inflammatory response to ECMO in sheep. The pig has a very similar coagulation system to humans and therefore makes a more appropriate model. We describe a porcine model of prolonged (48 hours) closed chest venovenous (VV) ECMO that we developed to investigate the inflammatory and coagulative response to different ECMO tubing materials. This model could be used to investigate any aspect of venovenous ECMO.

Original language	English (US)
Pages (from-to)	488-495
Number of pages	8
Journal	ASAIO Journal
Volume	45
Issue number	5
DOIs	https://doi.org/10.1097/00002480-199909000-00023
State	Published - 1999
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Bioengineering
Biomaterials
Biomedical Engineering

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10.1097/00002480-199909000-00023

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abstract = "The sheep has been the standard laboratory animal for extracorporeal membrane oxygenation (ECMO) research for many years and has proven to be an invaluable and reliable model. However the coagulation system of the sheep is significantly different from humans. These differences make it difficult to investigate the coagulative and inflammatory response to ECMO in sheep. The pig has a very similar coagulation system to humans and therefore makes a more appropriate model. We describe a porcine model of prolonged (48 hours) closed chest venovenous (VV) ECMO that we developed to investigate the inflammatory and coagulative response to different ECMO tubing materials. This model could be used to investigate any aspect of venovenous ECMO.",

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AU - Scott, Richard

AU - Killer, Hilliary M.

AU - Jarvis, Martin A.

AU - Kolvekar, Shyam

AU - Forbes, Derek

AU - Firmin, Richard K.

PY - 1999

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AB - The sheep has been the standard laboratory animal for extracorporeal membrane oxygenation (ECMO) research for many years and has proven to be an invaluable and reliable model. However the coagulation system of the sheep is significantly different from humans. These differences make it difficult to investigate the coagulative and inflammatory response to ECMO in sheep. The pig has a very similar coagulation system to humans and therefore makes a more appropriate model. We describe a porcine model of prolonged (48 hours) closed chest venovenous (VV) ECMO that we developed to investigate the inflammatory and coagulative response to different ECMO tubing materials. This model could be used to investigate any aspect of venovenous ECMO.

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A porcine model of prolonged closed chest venovenous extracorporeal membrane oxygenation

Abstract

ASJC Scopus subject areas

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