A porcine model of prolonged closed chest venovenous extracorporeal membrane oxygenation

Giles J. Peek, Richard Scott, Hilliary M. Killer, Martin A. Jarvis, Shyam Kolvekar, Derek Forbes, Richard K. Firmin

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The sheep has been the standard laboratory animal for extracorporeal membrane oxygenation (ECMO) research for many years and has proven to be an invaluable and reliable model. However the coagulation system of the sheep is significantly different from humans. These differences make it difficult to investigate the coagulative and inflammatory response to ECMO in sheep. The pig has a very similar coagulation system to humans and therefore makes a more appropriate model. We describe a porcine model of prolonged (48 hours) closed chest venovenous (VV) ECMO that we developed to investigate the inflammatory and coagulative response to different ECMO tubing materials. This model could be used to investigate any aspect of venovenous ECMO.

Original languageEnglish (US)
Pages (from-to)488-495
Number of pages8
JournalASAIO Journal
Issue number5
StatePublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


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