A new era of studying p53-mediated transcription activation

Wei-Li Liu; Robert A. Coleman; Sameer K. Singh

doi:10.1080/21541264.2017.1345354

A new era of studying p53-mediated transcription activation

Wei-Li Liu
, Robert A. Coleman
, Sameer K. Singh

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

To prevent tumorigenesis, p53 stimulates transcription by facilitating the recruitment of the transcription machinery on target gene promoters. Cryo-Electron Microscopy studies on p53-bound RNA Polymerase II (Pol II) reveal that p53 structurally regulates Pol II to affect its DNA binding and elongation, providing new insights into p53-mediated transcriptional regulation.

Original language	English (US)
Pages (from-to)	102-107
Number of pages	6
Journal	Transcription
Volume	9
Issue number	2
DOIs	https://doi.org/10.1080/21541264.2017.1345354
State	Published - Mar 15 2018

Keywords

3D structure
RNA polymerase II
cryo-electron microscopy
p53
transcription activation

ASJC Scopus subject areas

Biotechnology
Biochemistry
Genetics

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10.1080/21541264.2017.1345354

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title = "A new era of studying p53-mediated transcription activation",

abstract = "To prevent tumorigenesis, p53 stimulates transcription by facilitating the recruitment of the transcription machinery on target gene promoters. Cryo-Electron Microscopy studies on p53-bound RNA Polymerase II (Pol II) reveal that p53 structurally regulates Pol II to affect its DNA binding and elongation, providing new insights into p53-mediated transcriptional regulation.",

keywords = "3D structure, RNA polymerase II, cryo-electron microscopy, p53, transcription activation",

author = "Wei-Li Liu and Coleman, \{Robert A.\} and Singh, \{Sameer K.\}",

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AU - Liu, Wei-Li

AU - Coleman, Robert A.

AU - Singh, Sameer K.

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Y1 - 2018/3/15

N2 - To prevent tumorigenesis, p53 stimulates transcription by facilitating the recruitment of the transcription machinery on target gene promoters. Cryo-Electron Microscopy studies on p53-bound RNA Polymerase II (Pol II) reveal that p53 structurally regulates Pol II to affect its DNA binding and elongation, providing new insights into p53-mediated transcriptional regulation.

AB - To prevent tumorigenesis, p53 stimulates transcription by facilitating the recruitment of the transcription machinery on target gene promoters. Cryo-Electron Microscopy studies on p53-bound RNA Polymerase II (Pol II) reveal that p53 structurally regulates Pol II to affect its DNA binding and elongation, providing new insights into p53-mediated transcriptional regulation.

KW - 3D structure

KW - RNA polymerase II

KW - cryo-electron microscopy

KW - p53

KW - transcription activation

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UR - https://www.scopus.com/pages/publications/85044029944#tab=citedBy

U2 - 10.1080/21541264.2017.1345354

DO - 10.1080/21541264.2017.1345354

M3 - Review article

C2 - 28795863

AN - SCOPUS:85044029944

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VL - 9

SP - 102

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IS - 2

ER -

A new era of studying p53-mediated transcription activation

Abstract

Keywords

ASJC Scopus subject areas

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