A neuroendocrine marker in tissues of the immune system

Ruth Hogue Angeletti, William F. Hickey

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


Antibodies to chromogranin, a secretory protein marker for the diffuse neuroendocrine system, were used to analyze rat lymphoreticular tissues by means of immunochemistry and immunohistochemistry. Chromogranin-positive cells were present in spleen, lymph node, thymus, and fetal liver. When these organs were gently dispersed and separated on a Ficoll gradient, the chromogranin- immunoreactive cells became enriched in the dense red-cell pellets. The unexpected distribution of these neuroendocrine cells in all immunologically relevant structures suggests that they may link the nervous and immunological systems.

Original languageEnglish (US)
Pages (from-to)89-90
Number of pages2
Issue number4721
StatePublished - 1985
Externally publishedYes

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