A multiscale computational model for simulating the kinetics of protein complex assembly

Jiawen Chen, Yinghao Wu

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Proteins fulfill versatile biological functions by interacting with each other and forming high-order complexes. Although the order in which protein subunits assemble is important for the biological function of their final complex, this kinetic information has received comparatively little attention in recent years. Here we describe a multiscale framework that can be used to simulate the kinetics of protein complex assembly. There are two levels of models in the framework. The structural details of a protein complex are reflected by the residue-based model, while a lower-resolution model uses a rigid-body (RB) representation to simulate the process of complex assembly. These two levels of models are integrated together, so that we are able to provide the kinetic information about complex assembly with both structural details and computational efficiency.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages11
StatePublished - 2018

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Coarse-grained simulation
  • Diffusion-reaction algorithm
  • Kinetic Monte Carlo
  • Multiscale modeling
  • Protein association rate
  • Protein complex assembly

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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