@article{417eb2c1400b48cda0a0aa3f1b38a8e6,
title = "A Multi-study Coordinated Meta-analysis of Pulmonary Function and Cognition in Aging",
abstract = "Background: Substantial research is dedicated to understanding the aging-related dynamics among individual differences in level, change, and variation across physical and cognitive abilities. Evaluating replicability and synthesizing these findings has been limited by differences in measurements and samples, and by study design and statistical analyses confounding between-person differences with within-person changes. In this article, we conducted a coordinated analysis and summary meta-analysis of new results on the aging-related dynamics linking pulmonary function and cognitive performance. Methods: We performed coordinated analysis of bivariate growth models in data from 20,586 participants across eight longitudinal studies to examine individual differences in baseline level, rate of change, and occasion-specific variability in pulmonary and cognitive functioning. Results were summarized using meta-analysis. Results: We found consistent but weak baseline and longitudinal associations in levels of pulmonary and cognitive functioning, but no associations in occasion-specific variability. Conclusions: Results provide limited evidence for a consistent link between simultaneous changes in pulmonary and cognitive function in a normal aging population. Further research is required to understand patterns of onset of decline and differences in rates of change within and across physical and cognitive functioning domains, both within-individuals and across countries and birth cohorts. Coordinated analysis provides an efficient and rigorous approach for replicating and comparing results across independent longitudinal studies.",
keywords = "Cognition, Cognitive aging, Longitudinal analysis, Normative aging, Pulmonary",
author = "Duggan, {Emily C.} and Piccinin, {Andrea M.} and Sean Clouston and Koval, {Andriy V.} and Annie Robitaille and Zammit, {Andrea R.} and Chenkai Wu and Brown, {Cassandra L.} and Lee, {Lewina O.} and Deborah Finkel and Beasley, {William H.} and Jeffrey Kaye and Terrera, {Graciela Muniz} and Mindy Katz and Lipton, {Richard B.} and Dorly Deeg and Bennett, {David A.} and {Praetorius Bj{\"o}rk}, Marcus and Boo Johansson and Avron Spiro and Jennifer Weuve and Hofer, {Scott M.}",
note = "Funding Information: Research reported in this article was supported by the National Institute on Aging (P01-AG043362; Integrative Analysis of Longitudinal Studies of Aging and Dementia). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. E.D. was supported by the Vanier Canada Graduate Scholarship, Natural Sciences and Engineering Research Council of Canada. The Einstein Aging Study (EAS) is supported by the National Institutes on Aging (P01-AG03949, K01-AG054700), by the Sylvia & Leonard Marx Foundation, and the Czap Foundation. The Health and Retirement Study (HRS) is supported by the National Institute on Aging (U01-AG009740) and the Michigan Center on the Demography of Aging (P30-AG012846). The Longitudinal Aging Study Amsterdam (LASA) is supported by the Dutch Ministry of Health, Welfare and Sports and VU University and VU University Medical Center. The Rush Memory and Aging Project (MAP) at RUSH University is supported by the National Institute on Aging (R01-AG17917). Avron Spiro was supported by a Senior Research Career Scientist Award from the Clinical Science Research and Development Service, U.S. Department of Veterans Affairs. L.L. was supported by funding from the National Institute on Aging (K08-AG048221). The VA Normative Aging Study (NAS) is a research component of MAVERIC and is supported by the VA Cooperative Studies Program/Epidemiologic Research Centers. The views expressed in this article are those of the authors and do not necessarily represent the views of the U.S. Department of Veterans Affairs or other support institutions. The OCTO-Twin study is supported by the National Institute on Aging (AG08861), the Swedish Research Council for Health, Working Life and Welfare (Epilife FAS Center and AGECAP 2013- 2300), the Adlerbertska Foundation, Hjalmar Svensson Foundation, Knut and Alice Wallenberg Foundation, the Wenner-Gren Foundations, Wilhelm and Martina Lundgrens Foundation, and Swedish Brain Power Consortium. The Swedish Adoption/Twin Study of Aging (SATSA) is supported by the National Institute on Aging (AG04563, AG10175), the MacArthur Foundation Research Network on Successful Aging, the Swedish Research Council for Health, Working Life and Welfare (97:0147:1B), and the Swedish Research Council. Funding Information: Research reported in this article was supported by the National Institute on Aging (P01-AG043362; Integrative Analysis of Longitudinal Studies of Aging and Dementia). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. E.D. was supported by the Vanier Canada Graduate Scholarship, Natural Sciences and Engineering Research Council of Canada. The Einstein Aging Study (EAS) is supported by the National Institutes on Aging (P01-AG03949, K01-AG054700), by the Sylvia & Leonard Marx Foundation, and the Czap Foundation. The Health and Retirement Study (HRS) is supported by the National Institute on Aging (U01-AG009740) and the Michigan Center on the Demography of Aging (P30-AG012846). The Longitudinal Aging Study Amsterdam (LASA) is supported by the Dutch Ministry of Health, Welfare and Sports and VU University and VU University Medical Center. The Rush Memory and Aging Project (MAP) at RUSH University is supported by the National Institute on Aging (R01-AG17917). Avron Spiro was supported by a Senior Research Career Scientist Award from the Clinical Science Research and Development Service, U.S. Department of Veterans Affairs. L.L. was supported by funding from the National Institute on Aging (K08-AG048221). The VA Normative Aging Study (NAS) is a research component of MAVERIC and is supported by the VA Cooperative Studies Program/Epidemiologic Research Centers. The views expressed in this article are those of the authors and do not necessarily represent the views of the U.S. Department of Veterans Affairs or other support institutions. The OCTO-Twin study is supported by the National Institute on Aging (AG08861), the Swedish Research Council for Health, Working Life and Welfare (Epilife FAS Center and AGECAP 2013– 2300), the Adlerbertska Foundation, Hjalmar Svensson Foundation, Knut and Alice Wallenberg Foundation, the Wenner-Gren Foundations, Wilhelm and Martina Lundgrens Foundation, and Swedish Brain Power Consortium. The Swedish Adoption/Twin Study of Aging (SATSA) is supported by the National Institute on Aging (AG04563, AG10175), the MacArthur Foundation Research Network on Successful Aging, the Swedish Research Council for Health, Working Life and Welfare (97:0147:1B), and the Swedish Research Council. Publisher Copyright: {\textcopyright} 2019 The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.",
year = "2019",
month = oct,
day = "4",
doi = "10.1093/gerona/glz057",
language = "English (US)",
volume = "74",
pages = "1793--1804",
journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",
number = "11",
}