@article{1293aa43069249d2b272d224947685fe,
title = "A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood",
abstract = "In a multi-stage analysis of 52,436 individuals aged 17-90 across diverse cohorts and biobanks, we train, test, and evaluate a polygenic risk score (PRS) for hypertension risk and progression. The PRS is trained using genome-wide association studies (GWAS) for systolic, diastolic blood pressure, and hypertension, respectively. For each trait, PRS is selected by optimizing the coefficient of variation (CV) across estimated effect sizes from multiple potential PRS using the same GWAS, after which the 3 trait-specific PRSs are combined via an unweighted sum called “PRSsum”, forming the HTN-PRS. The HTN-PRS is associated with both prevalent and incident hypertension at 4-6 years of follow up. This association is further confirmed in age-stratified analysis. In an independent biobank of 40,201 individuals, the HTN-PRS is confirmed to be predictive of increased risk for coronary artery disease, ischemic stroke, type 2 diabetes, and chronic kidney disease.",
author = "{the NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium} and Nuzulul Kurniansyah and Goodman, {Matthew O.} and Kelly, {Tanika N.} and Tali Elfassy and Wiggins, {Kerri L.} and Bis, {Joshua C.} and Xiuqing Guo and Walter Palmas and Taylor, {Kent D.} and Lin, {Henry J.} and Jeffrey Haessler and Yan Gao and Daichi Shimbo and Smith, {Jennifer A.} and Bing Yu and Feofanova, {Elena V.} and Smit, {Roelof A.J.} and Zhe Wang and Hwang, {Shih Jen} and Simin Liu and Sylvia Wassertheil-Smoller and Manson, {Jo Ann E.} and Lloyd-Jones, {Donald M.} and Rich, {Stephen S.} and Loos, {Ruth J.F.} and Susan Redline and Adolfo Correa and Charles Kooperberg and Myriam Fornage and Kaplan, {Robert C.} and Psaty, {Bruce M.} and Rotter, {Jerome I.} and Arnett, {Donna K.} and Morrison, {Alanna C.} and Nora Franceschini and Daniel Levy and Bis, {Joshua C.} and Xiuqing Guo and Taylor, {Kent D.} and Lin, {Henry J.} and Jeffrey Haessler and Yan Gao and Smith, {Jennifer A.} and Sylvia Wassertheil-Smoller and Manson, {Jo Ann E.} and Rich, {Stephen S.} and Adolfo Correa and Charles Kooperberg and Kaplan, {Robert C.} and Rotter, {Jerome I.}",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
day = "1",
doi = "10.1038/s41467-022-31080-2",
language = "English (US)",
volume = "13",
journal = "Nature communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}
