A multi-center prospective cohort study of benign breast disease and risk of subsequent breast cancer

Geoffrey C. Kabat, Joan G. Jones, Neal Olson, Abdissa Negassa, Catherine Duggan, Mindy Ginsberg, Rita A. Kandel, Andrew G. Glass, Thomas E. Rohan

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


Objective We used a nested case-control design within a large, multi-center cohort of women who underwent a biopsy for benign breast disease (BBD) to assess the association of broad histologic groupings and specific histologic entities with risk of breast cancer. Methods Cases were all women who had a biopsy for BBD and who subsequently developed breast cancer; controls were individually matched to cases and were women with a biopsy for BBD who did not develop breast cancer in the same follow-up interval as that for the cases. After exclusions, 1,239 records (615 cases and 624 controls) were available for analysis. We used conditional logistic regression to estimate odds ratios and 95% confidence intervals (CIs). Results Relative to non-proliferative BBD/normal pathology, the multivariable-adjusted odds ratio for proliferative lesions without atypia was 1.45 (95% CI 1.10-1.90), and that for atypical hyperplasia was 5.27 (95% CI 2.29-12.15). The presence of multiple foci of columnar cell hyperplasia and of complex fibroadenoma without atypia was associated with a non-significantly increased risk of breast cancer, whereas sclerosing adenosis, radial scar, and papilloma showed no association with risk. Conclusion Our results indicate that, compared to women with normal pathology/non-proliferative disease, women with proliferative disease without atypia have a modestly increased risk of breast cancer, whereas women with atypical hyperplasia have a substantially increased risk.

Original languageEnglish (US)
Pages (from-to)821-828
Number of pages8
JournalCancer Causes and Control
Issue number6
StatePublished - Jun 2010


  • Atypical hyperplasia
  • Benign breast disease
  • Breast cancer
  • Proliferative disease

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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