TY - JOUR
T1 - A longitudinal resource for studying connectome development and its psychiatric associations during childhood
AU - Tobe, Russell H.
AU - MacKay-Brandt, Anna
AU - Lim, Ryan
AU - Kramer, Melissa
AU - Breland, Melissa M.
AU - Tu, Lucia
AU - Tian, Yiwen
AU - Trautman, Kristin Dietz
AU - Hu, Caixia
AU - Sangoi, Raj
AU - Alexander, Lindsay
AU - Gabbay, Vilma
AU - Castellanos, F. Xavier
AU - Leventhal, Bennett L.
AU - Craddock, R. Cameron
AU - Colcombe, Stanley J.
AU - Franco, Alexandre R.
AU - Milham, Michael P.
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Most psychiatric disorders are chronic, associated with high levels of disability and distress, and present during pediatric development. Scientific innovation increasingly allows researchers to probe brain-behavior relationships in the developing human. As a result, ambitions to (1) establish normative pediatric brain development trajectories akin to growth curves, (2) characterize reliable metrics for distinguishing illness, and (3) develop clinically useful tools to assist in the diagnosis and management of mental health and learning disorders have gained significant momentum. To this end, the NKI-Rockland Sample initiative was created to probe lifespan development as a large-scale multimodal dataset. The NKI-Rockland Sample Longitudinal Discovery of Brain Development Trajectories substudy (N = 369) is a 24- to 30-month multi-cohort longitudinal pediatric investigation (ages 6.0–17.0 at enrollment) carried out in a community-ascertained sample. Data include psychiatric diagnostic, medical, behavioral, and cognitive phenotyping, as well as multimodal brain imaging (resting fMRI, diffusion MRI, morphometric MRI, arterial spin labeling), genetics, and actigraphy. Herein, we present the rationale, design, and implementation of the Longitudinal Discovery of Brain Development Trajectories protocol.
AB - Most psychiatric disorders are chronic, associated with high levels of disability and distress, and present during pediatric development. Scientific innovation increasingly allows researchers to probe brain-behavior relationships in the developing human. As a result, ambitions to (1) establish normative pediatric brain development trajectories akin to growth curves, (2) characterize reliable metrics for distinguishing illness, and (3) develop clinically useful tools to assist in the diagnosis and management of mental health and learning disorders have gained significant momentum. To this end, the NKI-Rockland Sample initiative was created to probe lifespan development as a large-scale multimodal dataset. The NKI-Rockland Sample Longitudinal Discovery of Brain Development Trajectories substudy (N = 369) is a 24- to 30-month multi-cohort longitudinal pediatric investigation (ages 6.0–17.0 at enrollment) carried out in a community-ascertained sample. Data include psychiatric diagnostic, medical, behavioral, and cognitive phenotyping, as well as multimodal brain imaging (resting fMRI, diffusion MRI, morphometric MRI, arterial spin labeling), genetics, and actigraphy. Herein, we present the rationale, design, and implementation of the Longitudinal Discovery of Brain Development Trajectories protocol.
UR - http://www.scopus.com/inward/record.url?scp=85132050375&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85132050375&partnerID=8YFLogxK
U2 - 10.1038/s41597-022-01329-y
DO - 10.1038/s41597-022-01329-y
M3 - Article
C2 - 35701428
AN - SCOPUS:85132050375
SN - 2052-4463
VL - 9
JO - Scientific Data
JF - Scientific Data
IS - 1
M1 - 300
ER -
