TY - JOUR
T1 - A longitudinal resource for studying connectome development and its psychiatric associations during childhood
AU - Tobe, Russell H.
AU - MacKay-Brandt, Anna
AU - Lim, Ryan
AU - Kramer, Melissa
AU - Breland, Melissa M.
AU - Tu, Lucia
AU - Tian, Yiwen
AU - Trautman, Kristin Dietz
AU - Hu, Caixia
AU - Sangoi, Raj
AU - Alexander, Lindsay
AU - Gabbay, Vilma
AU - Castellanos, F. Xavier
AU - Leventhal, Bennett L.
AU - Craddock, R. Cameron
AU - Colcombe, Stanley J.
AU - Franco, Alexandre R.
AU - Milham, Michael P.
N1 - Funding Information:
We thank additional team members who supported data acquisition and management: Alexis Akeyson, Ayesha Anwar, Julia Beatini, Brian Bengyak, Sinead Burrows, Jerlyne Calixte, Brian Carbone, Stephanie Carelli, Steven Carter, Tiffany Chang, Maya Charan, Danny Chon, CaraSue Doriguzzi, Jesenya DeLeon, Cornel Duhaney, Lauren Futterman, Chelsea Gessner, Alyssa Giannone, Gwen Geisler, Jamie Glass, Natacha Gordon, Courtney Gray, Caitlin Hinz, Erica Ho, Steven Homan, Olive Hwang, Christy Joseph, Stephanie Kamiel, Michelle Kaplan, Jessica Kastin, Alexis Lieval, George Lopez, Amalia McDonald, Randy Moran, Casie Morgan, Laura Panek, John Pellman, Anna Rachlin, Hayley Reed, Paula Roa, Shruti Ray, Allison Rolfe, Margaret Ryan, Sheela Sajan, Christine Santiago, Eszter Schoell, Richard Sinnig, Melissa Sital, Elise Taverna, Betty Varghese, Lauren Walden, Abigail Waters, Steven Zavitz. We are grateful to Kathleen Cuneo PhD for her clinical review and participant feedback. We thank collaborators at the TReNDS Center for insights and support in electronic data capture and distribution: Vincent D Calhoun, William Courtney, Margaret King, and Dylan Wood. Additionally, we thank Alan Evans, Samir Das, and the LORIS team for the open availability of their software, as well as assistance through their support forum. We thank numerous expert consultants who contributed to the core NKI-RS protocol development: Bharat Biswal, Barbara Coffey, Christine L. Cox, Adriana Di Martino, Matthew J. Hoptman, Daniel C. Javitt, A. M. Claire Kelly, Harold S. Koplewicz, Kate Brody Nooner, Eva Petkova, Nunzio Pomara, Philip T. Reiss and John J. Sidtis. We would like to thank the AWS Open Data Sponsorship Program for storage support. We thank the numerous community partners, research participants, and families that contributed to the NKI-RS. The Longitudinal Discovery of Brain Development Trajectories was principally supported by NIH U01MH099059 (PI Milham). A subset of participants had baseline characterizations from the core enhanced NKI-RS protocol NIMH BRAINS R01MH094639-01 (PI Milham). Additional support was provided by NIH R01MH101555 (PI Craddock), NIH R01AG047596 (MPIs Milham and Colcombe), and the Child Mind Institute (1FDN2012-1). Funding for key personnel also provided in part by the New York State Office of Mental Health, NIH R01MH120601 (PI Gabbay), and Research Foundation for Mental Hygiene. Nancy Duan, Dawn Thomsen, and the Communications Team assisted in the generation of advertising materials and strategies.
Funding Information:
We thank additional team members who supported data acquisition and management: Alexis Akeyson, Ayesha Anwar, Julia Beatini, Brian Bengyak, Sinead Burrows, Jerlyne Calixte, Brian Carbone, Stephanie Carelli, Steven Carter, Tiffany Chang, Maya Charan, Danny Chon, CaraSue Doriguzzi, Jesenya DeLeon, Cornel Duhaney, Lauren Futterman, Chelsea Gessner, Alyssa Giannone, Gwen Geisler, Jamie Glass, Natacha Gordon, Courtney Gray, Caitlin Hinz, Erica Ho, Steven Homan, Olive Hwang, Christy Joseph, Stephanie Kamiel, Michelle Kaplan, Jessica Kastin, Alexis Lieval, George Lopez, Amalia McDonald, Randy Moran, Casie Morgan, Laura Panek, John Pellman, Anna Rachlin, Hayley Reed, Paula Roa, Shruti Ray, Allison Rolfe, Margaret Ryan, Sheela Sajan, Christine Santiago, Eszter Schoell, Richard Sinnig, Melissa Sital, Elise Taverna, Betty Varghese, Lauren Walden, Abigail Waters, Steven Zavitz. We are grateful to Kathleen Cuneo PhD for her clinical review and participant feedback. We thank collaborators at the TReNDS Center for insights and support in electronic data capture and distribution: Vincent D Calhoun, William Courtney, Margaret King, and Dylan Wood. Additionally, we thank Alan Evans, Samir Das, and the LORIS team for the open availability of their software, as well as assistance through their support forum. We thank numerous expert consultants who contributed to the core NKI-RS protocol development: Bharat Biswal, Barbara Coffey, Christine L. Cox, Adriana Di Martino, Matthew J. Hoptman, Daniel C. Javitt, A. M. Claire Kelly, Harold S. Koplewicz, Kate Brody Nooner, Eva Petkova, Nunzio Pomara, Philip T. Reiss and John J. Sidtis. We would like to thank the AWS Open Data Sponsorship Program for storage support. We thank the numerous community partners, research participants, and families that contributed to the NKI-RS. The Longitudinal Discovery of Brain Development Trajectories was principally supported by NIH U01MH099059 (PI Milham). A subset of participants had baseline characterizations from the core enhanced NKI-RS protocol NIMH BRAINS R01MH094639-01 (PI Milham). Additional support was provided by NIH R01MH101555 (PI Craddock), NIH R01AG047596 (MPIs Milham and Colcombe), and the Child Mind Institute (1FDN2012-1). Funding for key personnel also provided in part by the New York State Office of Mental Health, NIH R01MH120601 (PI Gabbay), and Research Foundation for Mental Hygiene. Nancy Duan, Dawn Thomsen, and the Communications Team assisted in the generation of advertising materials and strategies.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Most psychiatric disorders are chronic, associated with high levels of disability and distress, and present during pediatric development. Scientific innovation increasingly allows researchers to probe brain-behavior relationships in the developing human. As a result, ambitions to (1) establish normative pediatric brain development trajectories akin to growth curves, (2) characterize reliable metrics for distinguishing illness, and (3) develop clinically useful tools to assist in the diagnosis and management of mental health and learning disorders have gained significant momentum. To this end, the NKI-Rockland Sample initiative was created to probe lifespan development as a large-scale multimodal dataset. The NKI-Rockland Sample Longitudinal Discovery of Brain Development Trajectories substudy (N = 369) is a 24- to 30-month multi-cohort longitudinal pediatric investigation (ages 6.0–17.0 at enrollment) carried out in a community-ascertained sample. Data include psychiatric diagnostic, medical, behavioral, and cognitive phenotyping, as well as multimodal brain imaging (resting fMRI, diffusion MRI, morphometric MRI, arterial spin labeling), genetics, and actigraphy. Herein, we present the rationale, design, and implementation of the Longitudinal Discovery of Brain Development Trajectories protocol.
AB - Most psychiatric disorders are chronic, associated with high levels of disability and distress, and present during pediatric development. Scientific innovation increasingly allows researchers to probe brain-behavior relationships in the developing human. As a result, ambitions to (1) establish normative pediatric brain development trajectories akin to growth curves, (2) characterize reliable metrics for distinguishing illness, and (3) develop clinically useful tools to assist in the diagnosis and management of mental health and learning disorders have gained significant momentum. To this end, the NKI-Rockland Sample initiative was created to probe lifespan development as a large-scale multimodal dataset. The NKI-Rockland Sample Longitudinal Discovery of Brain Development Trajectories substudy (N = 369) is a 24- to 30-month multi-cohort longitudinal pediatric investigation (ages 6.0–17.0 at enrollment) carried out in a community-ascertained sample. Data include psychiatric diagnostic, medical, behavioral, and cognitive phenotyping, as well as multimodal brain imaging (resting fMRI, diffusion MRI, morphometric MRI, arterial spin labeling), genetics, and actigraphy. Herein, we present the rationale, design, and implementation of the Longitudinal Discovery of Brain Development Trajectories protocol.
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U2 - 10.1038/s41597-022-01329-y
DO - 10.1038/s41597-022-01329-y
M3 - Article
C2 - 35701428
AN - SCOPUS:85132050375
SN - 2052-4463
VL - 9
JO - Scientific Data
JF - Scientific Data
IS - 1
M1 - 300
ER -
