@article{1bd9fd15bc18498c9ce8c5f829064df7,
title = "A herpes simplex virus (HSV)-2 single-cycle candidate vaccine deleted in glycoprotein D protects male mice from lethal skin challenge with clinical isolates of HSV-1 and HSV-2",
abstract = "Herpes simplex virus (HSV) infections manifest as recurrent oral or genital mucosal lesions, meningoencephalitis, corneal blindness, and perinatal disease. Subunit vaccines have advanced into the clinic without success. None were tested preclinically in male mice. We compared a single-cycle candidate vaccine deleted in HSV-2 glycoprotein D (ΔgD-2) and subunit gD-2 or gD-1 protein vaccines in a male murine skin model. The ΔgD-2 provided complete protection against 10 times the lethal dose of HSV-1 or HSV-2 clinical isolates, and no latent virus was detected, whereas gD-1- and gD-2-adjuvanted proteins provided little or no protection. Protection correlated with Fc receptor activating but not neutralizing antibody titers.",
keywords = "ADCC, HSV, Vaccine",
author = "Clare Burn and Natalie Ramsey and Garforth, {Scott J.} and Steven Almo and Jacobs, {William R.} and Herold, {Betsy C.}",
note = "Funding Information: Financial support. This work was funded by the National Institutes of Health (Grant RO1 AI117321-01; to W. R. J. J. and B. C. H.) and X-VAX Technology, Inc. C. B. is supported by an HHMI International Student Research Fellowship. Funding Information: We thank John Kim for technical assistance. We are also grateful to Mei Cong, Aileen Paguio, and Vanessa Ott at Promega for providing the murine FcγRIV activation assays. This work was funded by the National Institutes of Health (Grant RO1 AI117321-01; to W. R. J. J. and B. C. H.) and X-VAX Technology, Inc. C. B. is supported by an HHMI International Student Research Fellowship. Publisher Copyright: {\textcopyright} The 2017 Author(s).",
year = "2018",
month = mar,
day = "1",
doi = "10.1093/infdis/jix628",
language = "English (US)",
volume = "217",
pages = "754--758",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "5",
}
