Abstract
Cortical auditory evoked potentials (CAEPs) were recorded at 1 and at 3 years of age in 19 children with Down's syndrome participating in a double blind trial of vitamin B6 and placebo begun in early infancy and continued for 3 years. CAEPs have previously been shown to have abnormally high amplitude in Down's syndrome patients. The CAEPs of the patients in the B6‐treated and placebo groups were compared. Only minor effects were found in the CAEPs recorded at 1 year of age. At 3 years of age, however, comparison of the B6‐treated group and the placebo group revealed significant differences in both amplitudes and latencies of CAEP components. Peak to peak amplitudes of prominent components were significantly lower in B6‐treated patients than in their placebo controls. Amplitude correlated in some cases with whole blood serotonin levels. Latencies for several prominent evoked peaks were significantly longer in B6‐treated patients.
Original language | English (US) |
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Pages (from-to) | 241-246 |
Number of pages | 6 |
Journal | Journal of Intellectual Disability Research |
Volume | 29 |
Issue number | 3 |
DOIs | |
State | Published - Sep 1985 |
Externally published | Yes |
ASJC Scopus subject areas
- Rehabilitation
- Arts and Humanities (miscellaneous)
- Neurology
- Clinical Neurology
- Psychiatry and Mental health