Abstract
The Caenorhabditis elegans caudal homolog, pal-1, is required for neurogenesis in the male tail. We show that expression of pal-1 in the postembryonic neuroblast cell V6 can be initiated by two alternate pathways. One pathway, acting in wild type, requires a regulatory element in the fifth pal-1 intron. The other pathway, independent of this element, is normally repressed by the newly identified gene sop-1, which encodes a homolog of the mammalian Mediator complex protein TRAP230. In sop-1 mutants, pal-1 is activated by a pathway that is stimulated by bar-1/β-catenin, a component of the Wnt signal transduction pathway. The results support a physiological role of the Mediator complex in conveying regulatory signals to the transcriptional apparatus.
Original language | English (US) |
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Pages (from-to) | 2161-2172 |
Number of pages | 12 |
Journal | Genes and Development |
Volume | 14 |
Issue number | 17 |
DOIs | |
State | Published - 2000 |
Keywords
- Cell fate
- Development
- Homeobox gene
- Regulation
- Transcription
ASJC Scopus subject areas
- General Medicine