PROJECT NARRATIVE: A precise temporal control of activated-regulated gene expression is an essential element of memory formation, and cognitive functions. Dysregulated expression of one such gene, Arc, has been implicated in memory deficits, altered cognitive performance and linked to several psychiatric disorders including schizophrenia, autism, and Alzheimer's. Therefore, understanding the dynamics of Arc gene expression and its regulation over time by imaging gene behavior will allow us to design optimal time windows of Arc level manipulations to ensure memory consolidation.
|Effective start/end date||3/15/21 → 2/28/23|
- NATIONAL INSTITUTE OF MENTAL HEALTH: $210,000.00
- NATIONAL INSTITUTE OF MENTAL HEALTH: $226,800.00
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