REPRODUCTION IN MUTANT SHEEP USED FOR THE STUDY OF HYPERBILIRUBINEMIA

  • Zolty, Ronald (PI)
  • Norris, David (PI)
  • Kaehny, William D. (PI)
  • Metz, Stewart (PI)
  • Robbins, Richard (PI)
  • Betz, George (PI)
  • Claman, Henry (PI)
  • Samuels, Mary H. (PI)
  • Franklin, Gary M. (PI)
  • Kohler, Peter (PI)
  • Bichet, Daniel (PI)
  • Groves, Bertron (PI)
  • [No Value], Bo Y. (PI)
  • Irons, Richard (PI)
  • Laudenslager, Mark (PI)
  • Emlen, Woodruff (PI)
  • Steigerwald, James (PI)
  • Hasiba, U.T.E. (PI)
  • Franks, Ronald (PI)
  • Tangel, Douglas (PI)
  • Canaris, G.A.Y. (PI)
  • Crapo, Phyllis (PI)
  • Dubovsky, Steven (PI)
  • Rosenberg, Neil L. (PI)
  • Hofeldt, Fred (PI)
  • Fuenzalida, Charles (PI)
  • Kern, Fred (PI)
  • Byyny, Richard L. (PI)
  • Hamilos, Daniel (PI)
  • Nies, Alan (PI)
  • Kolterman, Orville (PI)
  • Boyko, Edward (PI)
  • Petty, Thomas (PI)
  • Olefsky, Jerrold (PI)
  • Ahnen, Dennis (PI)
  • Moore, Lorna (PI)
  • King, Talmadge (PI)
  • Badesch, David B. (PI)
  • Garg, Satish (PI)
  • Spahn, Joseph (PI)
  • Weintraub, Phillip (PI)
  • Melanson, Edward (PI)
  • Kotzin, Brian (PI)
  • Wamboldt, Marianne (PI)
  • Francis, Coni (PI)
  • Wolfel, Eugene (PI)
  • Lowes, Brian (PI)
  • Bessesen, Daniel Holland (PI)
  • Benson, Constance (PI)
  • Routes, Jack (PI)
  • Hamman, Richard (PI)
  • Zamora, Martin (PI)
  • Freedman, Robert (PI)
  • Deitrich, Richard (PI)
  • Martin, Richard (PI)
  • Kraft, Monica (PI)
  • Bender, Bruce (PI)
  • Peloquin, Charles Arthur (PI)
  • Horton, Tracy (PI)
  • Thompson, Holly (PI)
  • Langmack, Esther (PI)
  • Wenzel, Sally (PI)
  • Kosmiski, Lisa (PI)
  • Moore, Lorna G. (PI)
  • Desouza, Christopher (PI)
  • Jones, Pamela (PI)
  • Rose, Cecile (PI)
  • Liu, Andy (PI)
  • Eisenbarth, George (PI)
  • Jones, J.I.M. (PI)
  • Gozansky, Wendolyn (PI)
  • Donahoo, W. Troy (PI)
  • Sonko, Bakary (PI)
  • Bell, Christopher (PI)
  • Wamboldt, Frederick Steven (PI)
  • Hill, James (PI)
  • Kaugars, Astrida (PI)
  • Liu, Andrew (PI)
  • Kraft, Monica (PI)
  • Gottschall, Eva (PI)
  • Hedlund, Tammy (PI)
  • Make, Barry (PI)
  • Scherer, Susan (PI)
  • Kram, Rodger (PI)
  • Crowley, Thomas (PI)
  • Francis, Coni (PI)
  • Lowes, Brian (PI)
  • Benson, Constance (PI)
  • Striebich, Christopher (PI)
  • Wasfi, Yasmine (PI)
  • Gates, Phillip (PI)
  • Wamboldt, Marianne (PI)
  • Seals, Douglas (PI)
  • Kelsay, Kimberly (PI)
  • Gerber, John G. (PI)
  • Fain, Pamela (PI)
  • Newman, Lee (PI)
  • Wenzel, Sally (PI)
  • Christou, Demetra (PI)
  • Farley, Claire (PI)
  • Badesch, David B. (PI)
  • Wyatt, Holly (PI)
  • Kohrt, Wendy (PI)
  • Desouza, Christopher (PI)
  • Schenkman, Margaret (PI)
  • Connick, Elizabeth (PI)
  • Eckel, Robert (PI)
  • Bessesen, Daniel Holland (PI)
  • Bowler, Russell Paul (PI)
  • Barbour, Linda (PI)
  • Bryan, Angela (PI)
  • Hiatt, William Read (PI)
  • Krebs, Nancy (PI)
  • Szefler, Stanley James (PI)
  • Horton, Tracy (PI)
  • Voelker, Dennis (PI)
  • van Pelt, Rachael (PI)
  • Fletcher, Courtney V. (PI)
  • Pacheco, Karin (PI)
  • Gottlieb, Peter (PI)
  • Leung, Donald (PI)
  • Regensteiner, Judith (PI)
  • Everson, Gregory Thomas (PI)
  • Klinnert, Mary D. (PI)
  • Bender, Bruce G. (PI)
  • Hutchison, Kent (PI)
  • Schwartz, Robert (PI)
  • Eisenbarth, George (PI)
  • Cornier, Marc-Andre (PI)
  • Wright, Kenneth (PI)
  • Bergman, Bryan (PI)
  • Bristow, Michael R. (PI)
  • Abraham, Edward (PI)
  • Maier, Lisa (PI)
  • Weber, Katherine (PI)
  • Capell, Warren (PI)
  • Norwood, Rachel (PI)
  • Manson, Spero (PI)
  • Stob, Nicole (PI)
  • Beske, Stacy (PI)
  • Aquilante, Christina (PI)
  • Melanson, Edward (PI)
  • Kosmiski, Lisa (PI)
  • Reusch, Jane (PI)
  • Hernandez, Theresa (PI)
  • Chonchol, Michel Benjamin (PI)
  • Linnebur, Sunny (PI)
  • Levi, Marilyn Eckstein (PI)
  • Hoody, Dorie (PI)
  • Albert, Richard (PI)
  • Gozansky, Wendolyn (PI)
  • Carten, Monica (PI)
  • Fontenot, Andrew (PI)
  • Higgins, Janine (PI)
  • Pierce, Gary L. (PI)
  • Barry, D.A.N. (PI)
  • Cambier, John C. (PI)
  • Schrier, Robert (PI)
  • Wierman, Margaret (PI)
  • Walders, Natalie (PI)
  • Kirkpatrick, Charles Harvey (PI)
  • Kozora, Elizabeth (PI)
  • Anderson, Peter (PI)
  • Stevens, Jennifer (PI)
  • Kulig, Clark (PI)
  • Dreskin, Stephen C. (PI)
  • Haugen, Bryan (PI)
  • Hall, Deborah (PI)
  • Rosen, Hugo Ramon (PI)
  • Striebich, Christopher (PI)
  • Draznin, Boris (PI)
  • Lichtenstein, K.E.N. (PI)
  • Bauer, Timothy (PI)
  • Rabinovitch, Nathan (PI)
  • Jankowski, Catherine (PI)
  • Mestroni, Luisa (PI)
  • Milgrom, Henry (PI)
  • Seals, Douglas (PI)
  • Martin, Richard (PI)
  • Liu, Andrew (PI)
  • Allen, David (PI)
  • Alfrey, Allen (PI)
  • Emlen, J. Woodruff (PI)
  • Linas, Stuart (PI)
  • Kelleher, Stephen (PI)
  • Stemmer, Salomon (PI)
  • Stumpf, David (PI)
  • vandepol, Christine (PI)
  • Block, Matthew (PI)
  • Teitelbaum, Issac (PI)
  • Reite, Martin (PI)
  • Schholey, Robert (PI)
  • Goff, John Sawyer (PI)
  • Shrier, Robert (PI)
  • Robertson, R. Paul (PI)
  • Boyson, Sally (PI)
  • Neldner, Kenneth (PI)
  • Schooley, Robert (PI)
  • Horsburgh, Charles (PI)
  • Hoffer, Barry (PI)
  • Hammermeister, Karl (PI)
  • Runn, Paul (PI)
  • Reiter, Michael (PI)
  • Baum, Kenneth (PI)
  • Gill, Kathyrn (PI)
  • Bloedow, Duane (PI)
  • Reeve, E. Basil (PI)
  • Echel, Robert (PI)
  • Distiller, Lawrence (PI)
  • Holmes, Joseph (PI)
  • Hollister, Alan (PI)
  • Woodward, John (PI)
  • Collier, David Harris (PI)
  • Phillip, Michael (PI)
  • Stegall, Mark (PI)
  • Levin, Myron (PI)
  • Gordon, Stuart (PI)
  • Hamridge, Michael (PI)
  • Huff, J.C. (PI)
  • Goodwin, Diane (PI)
  • Burks, Jack (PI)
  • Gartner, Stephanie (PI)
  • Bernanu, Paulos (PI)
  • Franks, John (PI)
  • Braun, Thomas (PI)
  • Kumpe, David (PI)
  • Gross, Cordell (PI)
  • Reveille, Matthew (PI)
  • Savage, Susan (PI)
  • Huff, J. Clark (PI)
  • Anderson, Robert (PI)
  • Wettlaufer, John (PI)
  • Wambolt, Marianne (PI)
  • Kruse, Carol (PI)
  • Bynny, Richard (PI)
  • Schwartz, M. (PI)
  • Singh, Shailini (PI)
  • Berhanu, Paulos (PI)
  • Gines, Pere (PI)
  • Albrecht, Bruce (PI)
  • Schriber, Robert (PI)
  • Dubofsky, Steven (PI)
  • Thompson, David (PI)
  • Hwang, Paul (PI)
  • Kindt, Glenn (PI)
  • Cohn, David (PI)
  • Drabkin, H. (PI)
  • Glode, L. Micheal (PI)
  • Golitz, Loren (PI)
  • Schlaff, William (PI)
  • Glode, Michael (PI)
  • Hay, William (PI)
  • Reveille, R. Matthew (PI)
  • Ridgeway, Eli Chester (PI)
  • Kern, Fred (PI)
  • Stuart, L. (PI)
  • Krueger, Michael (PI)
  • Frontiera, Michael (PI)
  • Manco-Johnson, Michael (PI)
  • Franklion, Gary (PI)
  • Horwitz, Lawrence (PI)
  • Marr, J. Joseph (PI)
  • Freed, Curt (PI)
  • Brand, Elliot (PI)
  • Robbins, Laurence (PI)
  • Teitelbaum, Isaac (PI)
  • Markley, Herbert (PI)
  • Daneshgari, Firouz (PI)
  • Cosby, Robert L. (PI)
  • Rector, William G. (PI)
  • Tan, Eng (PI)
  • St. Geme, Joseph W. (PI)
  • Halgrimson, Charles (PI)
  • Jacobson, Eugene (PI)
  • Groah, Suzanne (PI)
  • Harris, R. (PI)
  • Champman, Arlene (PI)
  • Yucha, Carolyn (PI)
  • Shapiro, Leland (PI)
  • Morelli, Joseph (PI)
  • Zisman, Lawrence S. (PI)
  • Ksiazek, Karen (PI)
  • Davy, Kevin (PI)
  • Brandenburg, Suzanne (PI)
  • Fennelly, Kevin (PI)
  • Crawford, Fred (PI)
  • Walsh, Patrick (PI)
  • Kraft, Andrew (PI)
  • Carroll, John (PI)
  • Burchenal, J. (PI)
  • Oman, Kathleen (PI)
  • Bilir, Bahri (PI)
  • Rowley, Jo Anne (PI)
  • Stolleer, Norman (PI)
  • Liliehei, Kevin (PI)
  • Tornblom, Kjell (PI)
  • Colton, Josh (PI)
  • Cook, James (PI)
  • Bessessen, Daniel (PI)
  • Cagnoni, Pablo (PI)
  • Buchanan, Thomas (PI)
  • Trouillot, Thomas (PI)
  • Hardin, Dana (PI)
  • Guzelian, Philip (PI)
  • Beresford, Thomas (PI)
  • Tyler, Kenneth L. (PI)
  • Brandenburg, Suzanne (PI)
  • Schooley, Robert Turner (PI)
  • Rodman, David (PI)
  • Kugelmas, Marcelo (PI)
  • Hoyt, Brian (PI)
  • Sutherland, Julie (PI)
  • O'Reilly, Randall Charles (PI)
  • Trotter, James F. (PI)
  • Dufour, Darna (PI)
  • Campbell, Thomas (PI)
  • David Crawford, E. (PI)
  • Grigsby, J.I.M. (PI)
  • Moreau, Kerrie (PI)
  • Gilden, Donald (PI)
  • Dumont, Larry (PI)
  • Guzelian, Philip (PI)
  • Brooks, Heather (PI)
  • Robertson, Michael (PI)
  • Johnson, Daniel (PI)
  • Stodieck, Louis (PI)
  • Wiseman, Alexander (PI)
  • Craighead, Edward (PI)
  • Christians, U.W.E. (PI)
  • Quan, Dianna (PI)
  • Boackle, Susan A. (PI)
  • Strom, Laura A. (PI)
  • Rollins, Yvonne (PI)
  • Barqawi, A.L. (PI)
  • Haughey, Heather (PI)
  • Donato, Anthony John (PI)
  • Heyn, Patricia (PI)
  • Corboy, John (PI)
  • Hassell, Kathryn (PI)
  • Liesnewski, Lisa (PI)
  • Echoff, Donald (PI)
  • Johnson, Lynn (PI)
  • Barron, Michelle A. (PI)
  • Aloia, Mark S. (PI)
  • Schrier, Robert W. (PI)
  • Rewers, Marian J. (PI)
  • Perreault, Leigh (PI)
  • Estacio, Raymond (PI)
  • Bunn, Paul A. (PI)
  • Sussman, Karl (PI)
  • Hayward, Anthony (PI)
  • David, Ikle (PI)
  • Jones, Roy (PI)
  • Robinson, Arthur (PI)
  • McGregor, James (PI)
  • Santhosh-Kumar, C. (PI)
  • Meier, Robert (PI)
  • Pincus, Diane (PI)
  • Belady, Petra (PI)
  • Collier, David (PI)
  • Doherty, Dennis (PI)
  • Neville, Hans (PI)
  • Ringel, Steven (PI)
  • Johnson, Steven (PI)
  • Jones, James (PI)
  • Shrestha, Roshan (PI)
  • Leavey, Patrick (PI)
  • Robinson, William A. (PI)
  • Adler, Lawrence (PI)
  • Wierman, Margaret (PI)
  • Draznin, Boris (PI)
  • Finkel, Terri (PI)
  • Lillehei, Kevin (PI)
  • Krebs, Nancy (PI)
  • Berl, Tomas (PI)
  • Rodman, David (PI)
  • Gabow, Patricia (PI)
  • Donahoo, W. Troy (PI)
  • Kuritzkes, Daniel (PI)
  • Connick, Elizabeth (PI)
  • Eckel, Robert H. (PI)
  • Reusch, Jane (PI)
  • Hiatt, William (PI)
  • Everson, Gregory T. (PI)
  • Klinnert, Mary D. (PI)
  • Lindenfeld, Joann (PI)
  • Ridgway, E. Chester (PI)
  • Haugen, Bryan (PI)
  • Abraham, William (PI)
  • Szefler, Stanley (PI)
  • Wamboldt, Frederick (PI)
  • Hill, James (PI)
  • Gerber, John (PI)
  • Crawford, E. David (PI)
  • Leung, Donald (PI)
  • Regensteiner, Judith (PI)
  • Bristow, Michael (PI)
  • Borish, Larry (PI)
  • Newman, L.E.E. (PI)
  • Schooley, Robert Turner (PI)
  • Nelson, Harold (PI)
  • Hambidge, K. Michael (PI)
  • Krugman, Richard (PI)
  • Kaehny, William D. (PI)
  • Emlen, J. Woodruff (PI)
  • Hasiba, U.T.E. (PI)
  • Robertson, R. Paul (PI)
  • Byyny, Richard L. (PI)
  • Huff, J.C. (PI)
  • Huff, J. Clark (PI)
  • Samuels, Mary H. (PI)
  • Franklin, Gary M. (PI)
  • [No Value], Bo Y. (PI)
  • Schwartz, M. (PI)
  • Reeve, E. Basil (PI)
  • Canaris, G.A.Y. (PI)
  • Drabkin, H. (PI)
  • Glode, L. Micheal (PI)
  • Rosenberg, Neil L. (PI)
  • Reveille, R. Matthew (PI)
  • Stuart, L. (PI)
  • Marr, J. Joseph (PI)
  • Cosby, Robert L. (PI)
  • Rector, William G. (PI)
  • St. Geme, Joseph W. (PI)
  • Badesch, David B. (PI)
  • Harris, R. (PI)
  • Schrier, Robert W. (PI)
  • Zisman, Lawrence S. (PI)
  • Burchenal, J. (PI)
  • Moore, Lorna G. (PI)
  • Jones, J.I.M. (PI)
  • Donahoo, W. Troy (PI)
  • Tyler, Kenneth L. (PI)
  • Gerber, John G. (PI)
  • Badesch, David B. (PI)
  • Rewers, Marian J. (PI)
  • Trotter, James F. (PI)
  • Klinnert, Mary D. (PI)
  • Fletcher, Courtney V. (PI)
  • Crawford, E. David (PI)
  • Bender, Bruce G. (PI)
  • Grigsby, J.I.M. (PI)
  • Bristow, Michael R. (PI)
  • Christians, U.W.E. (PI)
  • Boackle, Susan A. (PI)
  • Pierce, Gary L. (PI)
  • Barry, D.A.N. (PI)
  • Strom, Laura A. (PI)
  • Barqawi, A.L. (PI)
  • Cambier, John C. (PI)
  • Dreskin, Stephen C. (PI)
  • Lichtenstein, K.E.N. (PI)
  • Barron, Michelle A. (PI)
  • Aloia, Mark S. (PI)
  • Gates, Phillip (PI)
  • O'Reilly, Randall Charles (PI)
  • Farley, Claire (PI)
  • Christou, Demetra (PI)
  • Dufour, Darna (PI)
  • Hutchison, Kent (PI)
  • Bergman, Bryan (PI)
  • Desouza, Christopher (PI)
  • Bryan, Angela (PI)
  • Wright, Kenneth (PI)
  • Moreau, Kerrie (PI)
  • Seals, Douglas (PI)
  • Estacio, Raymond (PI)
  • Bunn, Paul A. (PI)
  • Sussman, Karl (PI)
  • Hayward, Anthony (PI)
  • David, Ikle (PI)
  • Jones, Roy (PI)
  • Robinson, Arthur (PI)
  • McGregor, James (PI)
  • Santhosh-Kumar, C. (PI)
  • Meier, Robert (PI)
  • Pincus, Diane (PI)
  • Belady, Petra (PI)
  • Collier, David (PI)
  • Doherty, Dennis (PI)
  • Neville, Hans (PI)
  • Ringel, Steven (PI)
  • Johnson, Steven (PI)
  • Jones, James (PI)
  • Shrestha, Roshan (PI)
  • Leavey, Patrick (PI)
  • Robinson, William A. (PI)
  • Adler, Lawrence (PI)
  • Wierman, Margaret (PI)
  • Draznin, Boris (PI)
  • Finkel, Terri (PI)
  • Lillehei, Kevin (PI)
  • Krebs, Nancy (PI)
  • Berl, Tomas (PI)
  • Rodman, David (PI)
  • Gabow, Patricia (PI)
  • Donahoo, W. Troy (PI)
  • Kuritzkes, Daniel (PI)
  • Connick, Elizabeth (PI)
  • Eckel, Robert H. (PI)
  • Reusch, Jane (PI)
  • Hiatt, William (PI)
  • Everson, Gregory T. (PI)
  • Klinnert, Mary D. (PI)
  • Lindenfeld, Joann (PI)
  • Ridgway, E. Chester (PI)
  • Haugen, Bryan (PI)
  • Abraham, William (PI)
  • Szefler, Stanley (PI)
  • Wamboldt, Frederick (PI)
  • Hill, James (PI)
  • Gerber, John (PI)
  • Crawford, E. David (PI)
  • Leung, Donald (PI)
  • Regensteiner, Judith (PI)
  • Bristow, Michael (PI)
  • Borish, Larry (PI)
  • Newman, L.E.E. (PI)
  • Schooley, Robert Turner (PI)
  • Nelson, Harold (PI)
  • Hambidge, K. Michael (PI)
  • Krugman, Richard (PI)

Project: Research project

Project Details

Description

A specific genetic strain of Corriedale sheep is used as an animal model
for the study of liver pathophysiology, specifically, hyperbilirubinemia
(Dubin-Johnson Syndrome). This project is concerned with increasing the
numbers of animals available for research by the controlled breeding of
individuals which genetically transmit this character. This project is
utilizing what is considered to be the only existing Corriedale sheep
homozygotic for this trait. Efforts are being made to obtain both
homozygous and heterozygous offspring from these highly inbred individuals.
Semen collected artificially from the homozygotic rams was diluted in
various cryoprotective extenders and then freeze preserved. This will
ensure the long term availability of male gametes for artificial
insemination. Overall this project allows prepetuation of this specific
gene pool and ensures availability of research animal for future
investigations of Dubin-Johnson Syndrome and related metabolic disorders.
StatusFinished
Effective start/end date12/1/78 → 3/31/10

Funding

  • National Institutes of Health

ASJC

  • Medicine(all)

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