Keyphrases
Malaria
100%
S Disease
100%
African Trypanosomiasis
100%
Chagas
100%
Phosphoribosyltransferase
100%
Purine
100%
Plasmodium Falciparum
77%
T. Brucei
55%
Trypanosoma Cruzi (T. cruzi)
55%
Trypanosoma
22%
Purine Salvage
22%
Parasitic Protozoa
22%
HGPRT
22%
Inhibitor Development
22%
Transition State
22%
Hypoxanthine
22%
African Sleeping Sickness
22%
Transition State Structure
11%
Trypanosoma Brucei
11%
Central America
11%
Successful Outcome
11%
High Morbidity
11%
Nucleotide Pool
11%
Transition State Inhibitors
11%
Nucleosides
11%
Auxotroph
11%
Human Disease
11%
X-ray Crystallography
11%
South America
11%
Potent Inhibitor
11%
Texas
11%
Prodrug
11%
Subnanomolar
11%
Hypoxanthine-guanine Phosphoribosyltransferase
11%
Cell Permeable
11%
Purine Biosynthesis
11%
Guanine
11%
Xanthine
11%
New Therapeutic Agents
11%
Parasiticidal Activity
11%
Drug Development
11%
Chemical Synthesis
11%
X-ray Structure
11%
Medical Needs
11%
Ribose
11%
Novel Inhibitors
11%
Transition State Theory
11%
Cell Culture
11%
Over 40
11%
Structure-based Inhibitor Design
11%
Site Conservation
11%
Trypanosoma Brucei Gambiense
11%
Quantum Chemical Computation
11%
New Leads
11%
Hereafter
11%
Unmet
11%
Active Sites
11%
Pyrophosphate
11%
Murine Model
11%
Pharmacology, Toxicology and Pharmaceutical Science
Purine Nucleoside Phosphorylase
100%
African Trypanosomiasis
100%
Diseases
100%
Purine
50%
Hypoxanthine
37%
Guanine
25%
Hypoxanthine Phosphoribosyltransferase
25%
Trypanosoma
25%
Xanthine
25%
Phosphoribosyltransferase
25%
Protozoan
25%
Nucleoside
12%
Trypanosoma Brucei Gambiense
12%
Prodrug
12%
Trypanosoma Brucei
12%
Trypanosoma Cruzi
12%
Guanosine Phosphate
12%
Lead Compound
12%
Cell Culture
12%
Inosine Phosphate
12%
Drug Development
12%
Pyrophosphate
12%
Plasmodium falciparum
12%
Ribose Phosphate
12%
Compounds of Lead
12%