Project Details
Description
Summary/Abstract
Metabolomics profiling of blood can detect subtle changes in metabolism that may presage the later
development of type 2 diabetes (T2D). This can both reveal early steps in the pathway to T2D, and also
provide a novel tool to identify high risk individuals. Hispanics/Latinos, the largest and fastest growing US
minority population, have a 66% higher prevalence of diabetes compared to non-Hispanic whites. US
Hispanics/Latinos are diverse in biological and sociocultural characteristics, and thus may have distinct diet,
lifestyle and gut microbiota patterns which likely influence metabolites implicated in T2D. The Main Goal of this
project is to identify metabolomics signatures for T2D risk and examine how diet, lifestyle and gut microbiota
influence metabolomics profiles associated with T2D. In particular, we propose to perform high-throughput
metabolomics profiling (>400 known and hundreds of unknown metabolites) of plasma from 1000 pairs of T2D
incident cases and matched controls in the Hispanic Community Health Study of Latinos (SOL) to identify
novel metabolomics signatures associated with incident T2D in US Hispanics/Latinos. In the SOL, we will
leverage existing extensive data on laboratory measures (e.g. fasting glucose and insulin, HbA1c, and 2-hr
post oral glucose tolerance test) and objectively measured behaviors (e.g., accelerometry, biomarker-
measured dietary factors) relevant to T2D. Utilizing gut microbiome data from an ongoing gut microbiome
project in the SOL, we will characterize gut microbial composition and functional features associated with
plasma metabolomics profiles implicated in T2D and examine the role of diet in modulating gut microbiota-
related metabolites. Metabolomics profiles implicated in T2D will be further examined in non-Hispanic cohorts
by including 1,500 pairs of T2D incident cases and matched controls from the Nurses' Health Study (NHS) and
the Health Professionals Follow-up Study (HPFS), two ongoing prospective cohort studies with the identical
metabolomics profiling platform, gut microbiome data and objectively measured diet and lifestyle factors. The
inclusion of both Hispanic and non-Hispanic cohorts may offer unique insights into the role of diet/lifestyle, gut
microbiota, and metabolic pathways in the development of T2D. The findings may have great potential to
identify novel targets for T2D prevention and intervention.
Status | Finished |
---|---|
Effective start/end date | 3/26/19 → 2/28/23 |
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases: $593,149.00
- National Institute of Diabetes and Digestive and Kidney Diseases: $501,127.00
- National Institute of Diabetes and Digestive and Kidney Diseases: $556,810.00
- National Institute of Diabetes and Digestive and Kidney Diseases: $556,810.00
- National Institute of Diabetes and Digestive and Kidney Diseases: $182,786.00
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