DPPOS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Diabetes Prevention Program was a multi-center study to determine if one of two interventions (an intensive lifestyle program or metformin) could prevent or delay the development of Type 2 diabetes in a high-risk population with impaired glucose tolerance. The results of this study, published in 2001, showed that both interventions were effective. The Diabetes Prevention Program Outcome Study (DPPOS) is a study of the original DPP cohort that seeks to determine the longer-term outcomes of the original DPP interventions. In addition, the study will provide observational insights regarding the clinical course of impaired glucose tolerance and new onset Type 2 diabetes. To date, approximately 84 percent of the original DPP cohort has enrolled in the DPPOS. At our local Einstein site, we have enrolled 74% of our original cohort and completion of the study visits is at our above study-wide levels.