Project Details
Description
The research discussed in this grant proposal addresses the role of
cytokines in the development of acute phase viral myocarditis and late
phase autoimmune myocarditis in CB3- infected susceptible A/J mice, a
model of human coxsackievirus myocarditis. Experiments will examine local
production of cytokines in the heart in response to CB3 infection or
myosin immunization. The effects of cytokines on inflammatory cell
populations and their activity, and the effects of cytokines on cardiac
myocyte contractility and physiology will be examined. The effect of
anticytokine therapy on the development of myocarditis will also be
examined. All research will be conducted in the Johns Hopkins School of Hygiene and
Public Health. The laboratories are well equipped, and contain all
equipment necessary to complete the described experiments.
Status | Finished |
---|---|
Effective start/end date | 12/1/77 → 11/30/07 |
ASJC
- Medicine(all)
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.