ALVAC-CEA-B7 VACCINE TREATMENT OF ADVANCED CEA EXPRESSING ADENOCARCINOMAS

  • Kaufman, Howard L. (PI)

Project: Research project

Project Details

Description

The purpose of this research study is to evaluate a new experimental treatment using a vaccine to treat cancer. The vaccine is a canarypox virus (ALVAC) that co-expresses the human carcinoembryonic antigen (CEA) and the so-stimulatory molecule B7-1. This is expected to activate T-cell responses against CEA-expressing tumor cells. This protocol is a phase I trial designed to determine the optimal dose of vaccine, side effects, clinical and immune responses. Increasing doses of virus will be used in patients with advanced CEA-expressing tumors by monthly intramuscular injections over 3 months. This study proposes to treat six patients at each dose of virus and will analyze immune responses after each immunization by in vitro T-cell assays and clinical responses after the 3 month treatment period. Patients without progression may be re-vaccinated.
StatusFinished
Effective start/end date10/1/98 → 9/30/01

Funding

  • National Center for Research Resources

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  • GENERAL CLINICAL RESEARCH CENTER M01 RR12248

    Spiegel, A. M. (PI), Purpura, D. P. (CoPI), Spiegel, A. A. M. (CoPI), Howard, A. A. A. (CoPI), Melman, A. (CoPI), Bloom, B. R. (CoPI), Diamond, B. B. (CoPI), Segal-isaacson, C. C. (CoPI), Stein, D. D. C. (CoPI), Schoenbaum, E. E. E. (CoPI), Kaskel, F. J. (CoPI), Ho, G. Y. (CoPI), Shamoon, H. H. (CoPI), Hetherington, H. P. (CoPI), Crystal, H. (CoPI), Roy-chowdhury, J. J. (CoPI), Pollard, J. J. W. (CoPI), Rieder, J. (CoPI), Crandall, J. P. (CoPI), Wylie-rosett, J. J. (CoPI), Pan, J. J. W. (CoPI), Rossetti, L. (CoPI), Weiss, L. M. (CoPI), Bigal, M. (CoPI), Hawkins, M. A. (CoPI), Brownlee, M. M. A. (CoPI), Alderman, M. H. (CoPI), Schilsky, M. L. (CoPI), Fabry, M. M. E. (CoPI), Roy-Chowdhury, N. (CoPI), Barzilai, N. N. J. (CoPI), Chua, S. C. (CoPI), Santoro, N. F. (CoPI), Kennan, R. P. (CoPI), Bookchin, R. (CoPI), Klein, R. R. M. (CoPI), Lipton, R. B. (CoPI), Burk, R. D. (CoPI), Nagel, R. L. (CoPI), Engel, S. S. S. (CoPI), Gupta, S. S. (CoPI), Somlo, S. S. (CoPI), Berk, S. S. (CoPI), Weber, T. T. J. (CoPI), Frishman, W. H. (CoPI), Noyer, C. M. (CoPI), Barzilai, N. (CoPI), Burk, R. D. (CoPI), Hawkins, M. A. (CoPI), Kaufman, H. L. (CoPI), Rubenstein, A. A. (CoPI), Shamoon, H. (CoPI), Stein, D. T. (CoPI), Wadler, S. H. (CoPI) & Wozniak, R. (CoPI)

    National Center for Research Resources

    9/30/97 → 11/30/97

    Project: Research project