Projects per year
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Collaborations and top research areas from the last five years
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Targeting the PNP - SAMHD1 synthetic-lethal combination in cancer
Schramm, V. L. (PI)
5/13/24 → 4/30/26
Project: Research project
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Targeting Clostridioides difficile with microbiome-sparing, resistant-proof anti-toxins
Schramm, V. L. (PI)
National Institute of Allergy and Infectious Diseases
4/1/21 → 3/31/26
Project: Research project
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Cancer Center Support Grant
Almo, S. C. (CoPI), Hogue-Angeletti, R. (CoPI), Augenlicht, L. H. (CoPI), Condeelis, J. S. (CoPI), Desai, K. (CoPI), Edelmann, W. (CoPI), Goldman, I. D. (CoPI), Greally, J. M. (CoPI), Herbst, L. H. (CoPI), Keller, S. M. (CoPI), Kim, M. Y. (CoPI), Mahmood, R. (CoPI), Montagna, C. (CoPI), Morrow, B. E. (CoPI), Pollard, J. W. (CoPI), Porcelli, S. A. (CoPI), Rohan, T. E. (CoPI), Scharff, M. D. (CoPI), Seither, R. (CoPI), Skoultchi, A. I. (CoPI), Sparano, J. A. (CoPI), Stanley, P. M. (CoPI), Chu, E. E. (PI), Bresnick, A. R. (CoPI), Skoultchi, A. I. (CoPI), Adedimeji, A. A. (CoPI), Beck, A. A. P. (CoPI), Blanchard, J. S. (CoPI), Halmos, B. B. (CoPI), Morrow, B. E. (CoPI), Diamond, B. B. (CoPI), Will, B. B. (CoPI), Rapkin, B. D. (CoPI), Chu, E. (CoPI), Montagna, C. C. (CoPI), Stein, D. T. (CoPI), Gaertner, D. D. J. (CoPI), Chu, E. E. (CoPI), Ho, G. Y. (CoPI), Goel, S. (CoPI), Hosgood, H. D. H. (CoPI), Strickler, H. H. D. (CoPI), Pollard, J. J. W. (CoPI), Condeelis, J. J. S. (CoPI), Dutcher, J. J. P. (CoPI), Greally, J. J. (CoPI), Backer, J. M. (CoPI), Sparano, J. J. A. (CoPI), Maianti, J. P. (CoPI), Aguirre-ghiso, J. J. A. (CoPI), Gritsman, K. K. (CoPI), Herbst, L. H. (CoPI), Augenlicht, L. H. (CoPI), Cannizzaro, L. A. (CoPI), Hackett, L. L. E. (CoPI), Scharff, M. M. D. (CoPI), Brenowitz, M. D. (CoPI), Kim, M. (CoPI), Ohri, N. N. (CoPI), Stanley, P. (CoPI), Gupta, R. R. K. (CoPI), Depinho, R. R. A. (CoPI), Kucherlapati, R. R. S. (CoPI), Schramm, V. L. (CoPI), Keller, S. M. (CoPI), Almo, S. C. (CoPI), Porcelli, S. S. A. (CoPI), Rohan, T. E. (CoPI), Steidl, U. U. G. (CoPI), Edelmann, W. (CoPI), Xue, X. X. N. (CoPI), Alderman, M. H. (CoPI), Atkinson, P. H. (CoPI), Bases, R. E. (CoPI), Birshstein, B. K. (CoPI), Bloom, B. R. (CoPI), Blumenfeld, O. O. (CoPI), Brenowitz, M. D. (CoPI), Brewer, F. C. (CoPI), Buhl, S. (CoPI), Chance, M. R. (CoPI), Chase, J. W. (CoPI), Childs, G. J. (CoPI), Depinho, R. (CoPI), Depinho, R. A. (CoPI), Duran-reynals, M. L. (CoPI), Dutcher, J. P. (CoPI), Eagle, H. (CoPI), Fant, J. (CoPI), Gaertner, D. J. (CoPI), Grills, G. (CoPI), Gupta, R. K. (CoPI), Horwitz, S. B. (CoPI), Horwitz, M. S. (CoPI), Hurwitz, J. (CoPI), Kadish, A. S. (CoPI), Klinger, H. P. (CoPI), Krauter, K. S. (CoPI), Kucherlapati, R. S. (CoPI), Levine, W. G. (CoPI), Lilly, F. (CoPI), Maio, J. J. (CoPI), Maitra, U. (CoPI), Makman, M. H. (CoPI), Marians, K. J. (CoPI), Nathenson, S. G. (CoPI), Orr, G. A. (CoPI), Peisach, J. (CoPI), Pickering, K. (CoPI), Rajan, T. V. (CoPI), Reid, L. M. (CoPI), Rubin, C. S. (CoPI), Russel, R. (CoPI), Satir, B. H. (CoPI), Schildkraut, C. L. (CoPI), Schulman, L. H. (CoPI), Serrano, L. J. (CoPI), Shapiro, L. (CoPI), Shin, S.-I. (CoPI), Wadler, S. H. (CoPI), Warner, J. R. (CoPI), West, M. (CoPI) & Wiernik, P. H. (CoPI)
6/1/85 → 6/30/26
Project: Research project
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PROTOZOAN PURINE PHOSPHORIBOSYLTRANSFERASES AS TARGETS TO TREAT MALARIA, AFRICAN TRYPANOSOMIASIS AND CHAGAS'S DISEASE
Schramm, V. L. (CoPI) & Schramm, V. L. (CoPI)
9/25/17 → 8/31/21
Project: Research project
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Continuous assay for the dNTP triphosphohydrolase of activated SAMHD1
Eskandari, R., Groom, D. P., Tamura, R. & Schramm, V. L., Jan 2026, In: Analytical Biochemistry. 708, 115966.Research output: Contribution to journal › Article › peer-review
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Kinetic Mechanism of the Emergent Anticancer Target, Human ADP-ribosyltransferase 1
Groom, D. P., Lopacinski, A., Garforth, S. J. & Schramm, V. L., May 6 2025, In: Biochemistry. 64, 9, p. 2077-2088 12 p.Research output: Contribution to journal › Article › peer-review
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The anti-cancer transition-state inhibitor MTDIA inhibits human MTAP, inducing autophagy in humanized yeast
Coorey, N. V., Tollestrup, I., Bircham, P. W., Sheridan, J. P., Evans, G. B., Schramm, V. L., Atkinson, P. H. & Munkacsi, A. B., Jun 2025, In: DMM Disease Models and Mechanisms. 18, 6, dmm052173.Research output: Contribution to journal › Article › peer-review
Open Access -
Transition State Analogs of Human DNPH1 Reveal Two Electrophile Migration Mechanisms
Wagner, A. G., Lang, T. B. D., Ledingham, E. T., Ghosh, A., Brooks, D., Eskandari, R., Suthagar, K., Almo, S. C., Lamiable-Oulaidi, F., Tyler, P. C. & Schramm, V. L., Feb 13 2025, In: Journal of Medicinal Chemistry. 68, 3, p. 3653-3672 20 p.Research output: Contribution to journal › Article › peer-review
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Transition State Analysis of SAMHD1 from Primary 18O, 33P, and Solvent Kinetic Isotope Effects
Ghosh, A. K., Groom, D. P. & Schramm, V. L., Mar 12 2025, In: Journal of the American Chemical Society. 147, 10, p. 8852-8863 12 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations