Susmita Kaushik

2023

A noncanonical function of SKP1 regulates the switch between autophagy and unconventional secretion

Li, J., Krause, G. J., Gui, Q., Kaushik, S., Rona, G., Zhang, Q., Liang, F. X., Dhabaria, A., Anerillas, C., Martindale, J. L., Vasilyev, N., Askenazi, M., Ueberheide, B., Nudler, E., Gorospe, M., Cuervo, A. M. & Pagano, M., Oct 2023, In: Science Advances. 9, 41, eadh1134.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

NGLY1 mutations cause protein aggregation in human neurons

Manole, A., Wong, T., Rhee, A., Novak, S., Chin, S. M., Tsimring, K., Paucar, A., Williams, A., Newmeyer, T. F., Schafer, S. T., Rosh, I., Kaushik, S., Hoffman, R., Chen, S., Wang, G., Snyder, M., Cuervo, A. M., Andrade, L., Manor, U., Lee, K., & 4 othersJones, J. R., Stern, S., Marchetto, M. C. & Gage, F. H., Dec 26 2023, In: Cell Reports. 42, 12, 113466.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2022

Chaperone-mediated autophagy regulates adipocyte differentiation

Kaushik, S., Juste, Y. R., Lindenau, K., Dong, S., Macho-González, A., Santiago-Fernández, O., McCabe, M., Singh, R., Gavathiotis, E. & Cuervo, A. M., Nov 2022, In: Science Advances. 8, 46, eabq2733.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Protective role of chaperone-mediated autophagy against atherosclerosis

Madrigal-Matute, J., de Bruijn, J., van Kuijk, K., Riascos-Bernal, D. F., Diaz, A., Tasset, I., Martín-Segura, A., Gijbels, M. J. J., Sander, B., Kaushik, S., Biessen, E. A. L., Tiano, S., Bourdenx, M., Krause, G. J., McCracken, I., Baker, A. H., Jin, H., Sibinga, N. E. S., Bravo-Cordero, J. J., Macian, F., & 6 othersSingh, R., Rensen, P. C. N., Berbeé, J. F. P., Pasterkamp, G., Sluimer, J. C. & Cuervo, A. M., Apr 5 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 14, e2121133119.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

2021

Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

Bourdenx, M., Martín-Segura, A., Scrivo, A., Rodriguez-Navarro, J. A., Kaushik, S., Tasset, I., Diaz, A., Storm, N. J., Xin, Q., Juste, Y. R., Stevenson, E., Luengo, E., Clement, C. C., Choi, S. J., Krogan, N. J., Mosharov, E. V., Santambrogio, L., Grueninger, F., Collin, L., Swaney, D. L., & 3 othersSulzer, D., Gavathiotis, E. & Cuervo, A. M., May 13 2021, In: Cell. 184, 10, p. 2696-2714.e25

Research output: Contribution to journal › Article › peer-review

Open Access

141 Scopus citations

Chaperone-mediated autophagy sustains haematopoietic stem-cell function

Dong, S., Wang, Q., Kao, Y. R., Diaz, A., Tasset, I., Kaushik, S., Thiruthuvanathan, V., Zintiridou, A., Nieves, E., Dzieciatkowska, M., Reisz, J. A., Gavathiotis, E., D’Alessandro, A., Will, B. & Cuervo, A. M., Mar 4 2021, In: Nature. 591, 7848, p. 117-123 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

133 Scopus citations

Reciprocal regulation of chaperone-mediated autophagy and the circadian clock

Juste, Y. R., Kaushik, S., Bourdenx, M., Aflakpui, R., Bandyopadhyay, S., Garcia, F., Diaz, A., Lindenau, K., Tu, V., Krause, G. J., Jafari, M., Singh, R., Muñoz, J., Macian, F. & Cuervo, A. M., Dec 2021, In: Nature Cell Biology. 23, 12, p. 1255-1270 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

2019

(-)-Oleocanthal and (-)-oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells

Goren, L., Zhang, G., Kaushik, S., Breslin, P. A. S., Du, Y. C. N. & Foster, D. A., Aug 1 2019, In: PloS one. 14, 8, e0216024.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

Hernandez, I., Luna, G., Rauch, J. N., Reis, S. A., Giroux, M., Karch, C. M., Boctor, D., Sibih, Y. E., Storm, N. J., Diaz, A., Kaushik, S., Zekanowski, C., Kang, A. A., Hinman, C. R., Cerovac, V., Guzman, E., Zhou, H., Haggarty, S. J., Goate, A. M., Fisher, S. K., & 2 othersCuervo, A. M. & Kosik, K. S., 2019, In: Science translational medicine. 11, 485

Research output: Contribution to journal › Article › peer-review

Open Access

62 Scopus citations

2018

Autophagy is required for sortilin-mediated degradation of apolipoprotein B100

Amengual, J., Guo, L., Strong, A., Madrigal-Matute, J., Wang, H., Kaushik, S., Brodsky, J. L., Rader, D. J., Cuervo, A. M. & Fisher, E. A., Feb 2018, In: Circulation research. 122, 4, p. 568-582 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD

Schultz, M. L., Krus, K. L., Kaushik, S., Dang, D., Chopra, R., Qi, L., Shakkottai, V. G., Cuervo, A. M. & Lieberman, A. P., Dec 1 2018, In: Nature communications. 9, 1, 3671.

Research output: Contribution to journal › Article › peer-review

Open Access

81 Scopus citations

2016

AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA

Kaushik, S. & Cuervo, A. M., Jan 1 2016, In: Autophagy. 12, 2, p. 432-438 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

157 Scopus citations

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

Mitchell, S. J., Madrigal-Matute, J., Scheibye-Knudsen, M., Fang, E., Aon, M., González-Reyes, J. A., Cortassa, S., Kaushik, S., Gonzalez-Freire, M., Patel, B., Wahl, D., Ali, A., Calvo-Rubio, M., Burón, M. I., Guiterrez, V., Ward, T. M., Palacios, H. H., Cai, H., Frederick, D. W., Hine, C., & 27 othersBroeskamp, F., Habering, L., Dawson, J., Beasley, T. M., Wan, J., Ikeno, Y., Hubbard, G., Becker, K. G., Zhang, Y., Bohr, V. A., Longo, D. L., Navas, P., Ferrucci, L., Sinclair, D. A., Cohen, P., Egan, J. M., Mitchell, J. R., Baur, J. A., Allison, D. B., Anson, R. M., Villalba, J. M., Madeo, F., Cuervo, A. M., Pearson, K. J., Ingram, D. K., Bernier, M. & De Cabo, R., Jun 14 2016, In: Cell metabolism. 23, 6, p. 1093-1112 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

309 Scopus citations

Structural and biological interaction of HSC-70 protein with phosphatidylserine in endosomal microautophagy

Morozova, K., Clement, C. C., Kaushik, S., Stiller, B., Arias, E., Ahmad, A., Rauch, J. N., Chatterjee, V., Melis, C., Scharf, B., Gestwicki, J. E., Cuervo, A. M., Zuiderweg, E. R. P. & Santambrogio, L., Aug 26 2016, In: Journal of Biological Chemistry. 291, 35, p. 18096-18106 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Scopus citations

2015

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

Kaushik, S. & Cuervo, A. M., Jun 1 2015, In: Nature Cell Biology. 17, 6, p. 759-770 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

467 Scopus citations

2012

Age-related oxidative stress compromises endosomal proteostasis

Cannizzo, E. S., Clement, C. C., Morozova, K., Valdor, R., Kaushik, S., Almeida, L. N., Follo, C., Sahu, R., Cuervo, A. M., Macian, F. & Santambrogio, L., Jul 26 2012, In: Cell Reports. 2, 1, p. 136-149 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

76 Scopus citations

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J. U., Ait-Mohamed, O., Ait-Si-Ali, S., Akematsu, T., Akira, S., Al-Younes, H. M., Al-Zeer, M. A., Albert, M. L., Albin, R. L., Alegre-Abarrategui, J., & 1,249 othersAleo, M. F. R., Alirezaei, M., Almasan, A., Almonte-Becerril, M., Amano, A., Amaravadi, R., Amarnath, S., Amer, A. O., Andrieu-Abadie, N., Anantharam, V., Ann, D. K., Anoopkumar-Dukie, S., Aoki, H., Apostolova, N., Arancia, G., Aris, J. P., Asanuma, K., Asare, N. Y. O., Ashida, H., Askanas, V., Askew, D. S., Auberger, P., Baba, M., Backues, S. K., Baehrecke, E. H., Bahr, B. A., Bai, X. Y., Bailly, Y., Baiocchi, R., Baldini, G., Balduini, W., Ballabio, A., Bamber, B. A., Bampton, E. T. W., Bánhegyi, G., Bartholomew, C. R., Bassham, D. C., Bast, R. C., Batoko, H., Bay, B. H., Beau, I., Béchet, D. M., Begley, T. J., Behl, C., Behrends, C., Bekri, S., Bellaire, B., Bendall, L. J., Benetti, L., Berliocchi, L., Bernardi, H., Bernassola, F., Besteiro, S., Bhatia-Kissova, I., Bi, X., Biard-Piechaczyk, M., Blum, J. S., Boise, L. H., Bonaldo, P., Boone, D. L., Bornhauser, B. C., Bortoluci, K. R., Bossis, I., Bost, F., Bourquin, J. P., Boya, P., Boyer-Guittaut, M., Bozhkov, P. V., Brady, N. R., Brancolini, C., Brech, A., Brenman, J. E., Brennand, A., Bresnick, E. H., Brest, P., Bridges, D., Bristol, M. L., Brookes, P. S., Brown, E. J., Brumell, J. H., Brunetti-Pierri, N., Brunk, U. T., Bulman, D. E., Bultman, S. J., Bultynck, G., Burbulla, L. F., Bursch, W., Butchar, J. P., Buzgariu, W., Bydlowski, S. P., Cadwell, K., Cahová, M., Cai, D., Cai, J., Cai, Q., Calabretta, B., Calvo-Garrido, J., Camougrand, N., Campanella, M., Campos-Salinas, J., Candi, E., Cao, L., Caplan, A. B., Carding, S. R., Cardoso, S. M., Carew, J. S., Carlin, C. R., Carmignac, V., Carneiro, L. A. M., Carra, S., Caruso, R. A., Casari, G., Casas, C., Castino, R., Cebollero, E., Cecconi, F., Celli, J., Chaachouay, H., Chae, H. J., Chai, C. Y., Chan, D. C., Chan, E. Y., Chang, R. C. H. C., Che, C. M., Chen, C. C., Chen, G. C., Chen, G. Q., Chen, M., Chen, Q., Chen, S. S. L., Chen, W. L., Chen, X., Chen, X., Chen, X., Chen, Y. G., Chen, Y., Chen, Y., Chen, Y. J., Chen, Z., Cheng, A., Cheng, C. H. K., Cheng, Y., Cheong, H., Cheong, J. H., Cherry, S., Chess-Williams, R., Cheung, Z. H., Chevet, E., Chiang, H. L., Chiarelli, R., Chiba, T., Chin, L. S., Chiou, S. H., Chisari, F. V., Cho, C. H. I., Cho, D. H., Choi, A. M. K., Choi, D. S., Choi, K. S. O., Choi, M. E., Chouaib, S., Choubey, D., Choubey, V., Chu, C. T., Chuang, T. H., Chueh, S. H., Chun, T., Chwae, Y. J., Chye, M. L., Ciarcia, R., Ciriolo, M. R., Clague, M. J., Clark, R. S. B., Clarke, P. G. H., Clarke, R., Codogno, P., Coller, H. A., Colombo, M. I., Comincini, S., Condello, M., Condorelli, F., Cookson, M. R., Coombs, G. H., Coppens, I., Corbalan, R., Cossart, P., Costelli, P., Costes, S., Coto-Montes, A., Couve, E., Coxon, F. P., Cregg, J. M., Crespo, J. L., Cronjé, M. J., Cuervo, A. M. A., Cullen, J. J., Czaja, M. J., D'Amelio, M., Darfeuille-Michaud, A., Davids, L. M., Davies, F. E., De Felici, M., de Groot, J. F., de Haan, C. A. M., De Martino, L., De Milito, A., De Tata, V., Debnath, J., Degterev, A., Dehay, B., Delbridge, L. M. D., Demarchi, F., Deng, Y. Z. H., Dengjel, J., Dent, P., Denton, D., Deretic, V., Desai, S. D., Devenish, R. J., Di Gioacchino, M., Di Paolo, G., Di Pietro, C., Díaz-Araya, G., Díaz-Laviada, I., Diaz-Meco, M. T., Diaz-Nido, J., Dikic, I., Dinesh-Kumar, S. P., Ding, W. X., Distelhorst, C. W., Diwan, A., Djavaheri-Mergny, M., Dokudovskaya, S., Dong, Z., Dorsey, F. C., Dosenko, V., Dowling, J. J., Doxsey, S., Dreux, M., Drew, M. E., Duan, Q., Duchosal, M. A., Duff, K., Dugail, I., Durbeej, M., Duszenko, M., Edelstein, C. L., Edinger, A. L., Egea, G., Eichinger, L., Eissa, N. T., Ekmekcioglu, S., El-Deiry, W. S., Elazar, Z., Elgendy, M., Ellerby, L. M., Eng, K. E. R., Engelbrecht, A. M., Engelender, S., Erenpreisa, J., Escalante, R., Esclatine, A., Eskelinen, E. L., Espert, L., Espina, V., Fan, H., Fan, J., Fan, Q. W., Fan, Z., Fang, S., Fang, Y., Fanto, M., Fanzani, A., Farkas, T., Farré, J. C., Faure, M., Fechheimer, M., Feng, C. G., Feng, J., Feng, Q., Feng, Y., Fésüs, L., Feuer, R., Figueiredo-Pereira, M. E., Fimia, G. M. A., Fingar, D. C., Finkbeiner, S., Finkel, T., Finley, K. D., Fiorito, F., Fisher, E. A., Fisher, P. B., Flajolet, M., Florez-McClure, M. L., Florio, S., Fon, E. A., Fornai, F., Fortunato, F., Fotedar, R., Fowler, D. H., Fox, H. S., Franco, R., Frankel, L. B., Fransen, M., Fuentes, J. M., Fueyo, J., Fujii, J., Fujisaki, K., Fujita, E., Fukuda, M., Furukawa, R. H., Gaestel, M., Gailly, P., Gajewska, M., Galliot, B., Galy, V., Ganesh, S., Ganetzky, B., Ganley, I. G., Gao, F. B., Gao, G. F., Gao, J., Garcia, L., Garcia-Manero, G., Garcia-Marcos, M., Garmyn, M., Gartel, A. L., Gatti, E., Gautel, M., Gawriluk, T. R., Gegg, M. E., Geng, J., Germain, M., Gestwicki, J. E., Gewirtz, D. A., Ghavami, S., Ghosh, P., Giammarioli, A. M., Giatromanolaki, A. N., Gibson, S. B., Gilkerson, R. W., Ginger, M. L., Ginsberg, H. N., Golab, J., Goligorsky, M. S., Golstein, P., Gomez-Manzano, C., Goncu, E., Gongora, C., Gonzalez, C. D., Gonzalez, R., González-Estévez, C., González-Polo, R. A. N., Gonzalez-Rey, E., Gorbunov, N. V., Gorski, S., Goruppi, S., Gottlieb, R. A., Gozuacik, D., Granato, G. E. L., Grant, G. D., Green, K. N., Gregorc, A., Gros, F., Grose, C., Grunt, T. W., Gual, P., Guan, J. L., Guan, K. L., Guichard, S. M., Gukovskaya, A. S., Gukovsky, I., Gunst, J., Gustafsson, A. B., Halayko, A. J., Hale, A. N., Halonen, S. K., Hamasaki, M., Han, F., Han, T., Hancock, M. K., Hansen, M., Harada, H., Harada, M., Hardt, S. E., Harper, J. W., Harris, A. L., Harris, J., Harris, S. D., Hashimoto, M., Haspel, J. A., Hayashi, S. I., Hazelhurst, L. A., He, C., He, Y. W., Hébert, M. J., Heidenreich, K. A., Helfrich, M. H., Helgason, G. V., Henske, E. P., Herman, B., Herman, P. K., Hetz, C., Hilfiker, S., Hill, J. A., Hocking, L. J., Hofman, P., Hofmann, T. G., Höhfeld, J., Holyoake, T. L., Hong, M. H., Hood, D. A., Hotamisligil, G. S., Houwerzijl, E. J., Høyer-Hansen, M., Hu, B., Hu, C. A. A., Hu, H. M., Hua, Y., Huang, C., Huang, J., Huang, S., Huang, W. P., Huber, T. B., Huh, W. K., Hung, T. H., Hupp, T. R., Hur, G. M. I., Hurley, J. B., Hussain, S. N. A., Hussey, P. J., Hwang, J. J. I., Hwang, S., Ichihara, A., Ilkhanizadeh, S., Inoki, K., Into, T., Iovane, V., Iovanna, J. L., Ip, N. Y., Isaka, Y., Ishida, H., Isidoro, C., Isobe, K. I., Iwasaki, A., Izquierdo, M., Izumi, Y., Jaakkola, P. M., Jäättelä, M., Jackson, G. R., Jackson, W. T., Janji, B., Jendrach, M., Jeon, J. H., Jeung, E. B., Jiang, H., Jiang, H., Jiang, J. X., Jiang, M., Jiang, Q., Jiang, X., Jiménez, A., Jin, M., Jin, S., Joe, C. O., Johansen, T., Johnson, D. E., Johnson, G. V. W., Jones, N. L., Joseph, B., Joseph, S. K., Joubert, A. M., Juhász, G., Juillerat-Jeanneret, L., Jung, C. H. W., Jung, Y. K., Kaarniranta, K., Kaasik, A., Kabuta, T., Kadowaki, M., Kagedal, K., Kamada, Y., Kaminskyy, V. O., Kampinga, H. H., Kanamori, H., Kang, C., Kang, K. B. E., Kang, K. I. L., Kang, R., Kang, Y. A., Kanki, T., Kanneganti, T. D., Kanno, H., Kanthasamy, A. G., Kanthasamy, A., Karantza, V., Kaushal, G. P., Kaushik, S., Kawazoe, Y., Ke, P. Y., Kehrl, J. H., Kelekar, A., Kerkhoff, C., Kessel, D. H., Khalil, H., Kiel, J. A. K. W., Kiger, A. A., Kihara, A., Kim, D. R. Y., Kim, D. H., Kim, D. H., Kim, E. K., Kim, H. R., Kim, J. S., Kim, J. H. U., Kim, J. C. H., Kim, J. K., Kim, P. K., Kim, S. W. H., Kim, Y. S., Kim, Y., Kimchi, A., Kimmelman, A. C., King, J. S., Kinsella, T. J., Kirkin, V., Kirshenbaum, L. A., Kitamoto, K., Kitazato, K., Klein, L., Klimecki, W. T., Klucken, J., Knecht, E., Ko, B. C. B., Koch, J. C., Koga, H., Koh, J. Y., Koh, Y. H. O., Koike, M., Komatsu, M., Kominami, E., Kong, H. J. E., Kong, W. J., Korolchuk, V. I., Kotake, Y., Koukourakis, M. I., Kouri Flores, J. B., Kovács, A. L., Kraft, C., Krainc, D., Krämer, H., Kretz-Remy, C., Krichevsky, A. M., Kroemer, G., Krüger, R., Krut, O., Ktistakis, N. T., Kuan, C. Y., Kucharczyk, R., Kumar, A., Kumar, R., Kumar, S., Kundu, M., Kung, H. J., Kurz, T., Kwon, H. J. E., La Spada, A. R., Lafont, F., Lamark, T., Landry, J., Lane, J. D., Lapaquette, P., Laporte, J. F., László, L., Lavandero, S., Lavoie, J. N., Layfield, R., Lazo, P. A., Le, W., Le Cam, L., Ledbetter, D. J., Lee, A. J. X., Lee, B. W., Lee, G. M. I., Lee, J., Lee, J. H., Lee, M., Lee, M. S., Lee, S. H. Y., Leeuwenburgh, C., Legembre, P., Legouis, R., Lehmann, M., Lei, H. Y., Lei, Q. Y., Leib, D. A., Leiro, J., Lemasters, J. J., Lemoine, A., Lesniak, M. S., Lev, D., Levenson, V. V., Levine, B., Levy, E., Li, F., Li, J. L., Li, L., Li, S., Li, W., Li, X. J., Li, Y. B., Li, Y. P., Liang, C., Liang, Q., Liao, Y. F., Liberski, P. P., Lieberman, A., Lim, H. J., Lim, K. L., Lim, K., Lin, C. F., Lin, F. C., Lin, J., Lin, J. D., Lin, K., Lin, W. W., Lin, W. C., Lin, Y. L., Linden, R., Lingor, P., Lippincott-Schwartz, J., Lisanti, M. P., Liton, P. B., Liu, B., Liu, C. F., Liu, K., Liu, L., Liu, Q. A., Liu, W., Liu, Y. C., Liu, Y., Lockshin, R. A., Lok, C. N., Lonial, S., Loos, B., Lopez-Berestein, G., López-Otín, C., Lossi, L., Lotze, M. T., Lőw, P., Lu, B., Lu, B., Lu, B., Lu, Z., Luciano, F., Lukacs, N. W., Lund, A. H., Lynch-Day, M. A., Ma, Y., Macian, F., MacKeigan, J. P., Macleod, K. F., Madeo, F., Maiuri, L., Maiuri, M. C. H., Malagoli, D., Malicdan, M. C. H. V., Malorni, W., Man, N., Mandelkow, E. M., Manon, S., Manov, I., Mao, K., Mao, X., Mao, Z., Marambaud, P., Marazziti, D., Marcel, Y. L., Marchbank, K., Marchetti, P., Marciniak, S. J., Marcondes, M., Mardi, M., Marfe, G., Mariño, G., Markaki, M., Marten, M. R., Martin, S. J., Martinand-Mari, C., Martinet, W., Martinez-Vicente, M., Masini, M., Matarrese, P., Matsuo, S., Matteoni, R., Mayer, A., Mazure, N. M., McConkey, D. J., McConnell, M. J., McDermott, C., McDonald, C., McInerney, G. M., McKenna, S. L., McLaughlin, B. A., McLean, P. J., McMaster, C. R., McQuibban, G. A., Meijer, A. J., Meisler, M. H., Meléndez, A., Melia, T. J., Melino, G., Mena, M. A., Menendez, J. A., Menna-Barreto, R. F. S., Menon, M. B., Menzies, F. M., Mercer, C. A., Merighi, A., Merry, D. E., Meschini, S., Meyer, C. G., Meyer, T. F., Miao, C. Y., Miao, J. Y., Michels, P. A. M., Michiels, C., Mijaljica, D., Milojkovic, A., Minucci, S., Miracco, C., Miranti, C. K., Mitroulis, I., Miyazawa, K., Mizushima, N., Mograbi, B., Mohseni, S., Molero, X., Mollereau, B., Mollinedo, F., Momoi, T., Monastyrska, I., Monick, M. M., Monteiro, M. J., Moore, M. 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C., Reggiori, F., Régnier-Vigouroux, A., Reichert, A. S., Reiners, J. J., Reiter, R. J., Ren, J., Revuelta, J. L., Rhodes, C. J., Ritis, K., Rizzo, E., Robbins, J., Roberge, M., Roca, H., Roccheri, M. C., Rocchi, S., Rodemann, H. P., Rodríguez de Córdoba, S., Rohrer, B., Roninson, I. B., Rosen, K., Rost-Roszkowska, M. M., Rouis, M., Rouschop, K. M. A., Rovetta, F., Rubin, B. P., Rubinsztein, D. C., Ruckdeschel, K., Rucker, E. B., Rudich, A., Rudolf, E., Ruiz-Opazo, N., Russo, R., Rusten, T. E. R., Ryan, K. M., Ryter, S. W., Sabatini, D. M., Sadoshima, J., Saha, T., Saitoh, T., Sakagami, H., Sakai, Y., Salekdeh, G. H. O., Salomoni, P., Salvaterra, P. M., Salvesen, G., Salvioli, R., Sanchez, A. M. J., Sánchez-Alcázar, J. A., Sánchez-Prieto, R., Sandri, M., Sankar, U., Sansanwal, P., Santambrogio, L., Saran, S., Sarkar, S., Sarwal, M., Sasakawa, C., Sasnauskiene, A., Sass, M., Sato, K., Sato, M., Schapira, A. H. V., Scharl, M., Schätzl, H. 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C., Uchiyama, Y., Ueno, T., Umekawa, M., Umemiya-Shirafuji, R., Unni, V. K., Vaccaro, M. I., Valente, E. M. A., Van den Berghe, G., van der Klei, I. J., van Doorn, W., van Dyk, L. F., van Egmond, M., van Grunsven, L. A., Vandenabeele, P., Vandenberghe, W. P., Vanhorebeek, I., Vaquero, E. C., Velasco, G., Vellai, T., Vicencio, J. M. I., Vierstra, R. D., Vila, M., Vindis, C., Viola, G., Viscomi, M. T. E., Voitsekhovskaja, O. V., von Haefen, C., Votruba, M., Wada, K., Wade-Martins, R., Walker, C. L., Walsh, C. M., Walter, J., Wan, X. B., Wang, A., Wang, C., Wang, D., Wang, F., Wang, F., Wang, G., Wang, H., Wang, H. G., Wang, H. D., Wang, J., Wang, K., Wang, M., Wang, R. C., Wang, X., Wang, X., Wang, Y. J., Wang, Y., Wang, Z., Wang, Z. C. H., Wang, Z., Wansink, D. G., Ward, D. M., Watada, H., Waters, S. L., Webster, P., Wei, L., Weihl, C. C., Weiss, W. A., Welford, S. M., Wen, L. P., Whitehouse, C. A., Whitton, J. L., Whitworth, A. J., Wileman, T., Wiley, J. W., Wilkinson, S., Willbold, D., Williams, R. L., Williamson, P. R., Wouters, B. G., Wu, C., Wu, D. C., Wu, W. K. K., Wyttenbach, A., Xavier, R. J., Xi, Z., Xia, P., Xiao, G., Xie, Z., Xie, Z., Xu, D. Z., Xu, J., Xu, L., Xu, X., Yamamoto, A., Yamamoto, A., Yamashina, S., Yamashita, M., Yan, X., Yanagida, M., Yang, D. S., Yang, E., Yang, J. M., Yang, S. Y. U., Yang, W., Yang, W. Y. U., Yang, Z., Yao, M. C., Yao, T. P., Yeganeh, B., Yen, W. L., Yin, J. J., Yin, X. M., Yoo, O. J., Yoon, G., Yoon, S. Y., Yorimitsu, T., Yoshikawa, Y., Yoshimori, T., Yoshimoto, K., You, H. J. I., Youle, R. J., Younes, A., Yu, L., Yu, L., Yu, S. W., Yu, W. H. A., Yuan, Z. M., Yue, Z., Yun, C. H., Yuzaki, M., Zabirnyk, O., Silva-Zacarin, E., Zacks, D., Zacksenhaus, E., Zaffaroni, N., Zakeri, Z., Zeh, H. J., Zeitlin, S. O., Zhang, H., Zhang, H. L., Zhang, J., Zhang, J. P., Zhang, L., Zhang, L., Zhang, M. Y., Zhang, X. D. O., Zhao, M., Zhao, Y. F., Zhao, Y., Zhao, Z. J., Zheng, X., Zhivotovsky, B., Zhong, Q., Zhou, C. Z., Zhu, C., Zhu, W. G., Zhu, X. F., Zhu, X., Zhu, Y., Zoladek, T., Zong, W. X., Zorzano, A., Zschocke, J. & Zuckerbraun, B., Apr 1 2012, In: Autophagy. 8, 4, p. 445-544 100 p.

Research output: Contribution to journal › Article › peer-review

2885 Scopus citations

Inhibitory effect of dietary lipids on chaperone-mediated autophagy

Rodriguez-Navarro, J. A., Kaushik, S., Koga, H., Dall'Armi, C., Shui, G., Wenk, M. R., Di Paolo, G. & Cuervo, A. M., Mar 20 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 12, p. E705-E714

Research output: Contribution to journal › Article › peer-review

Open Access

176 Scopus citations

Loss of autophagy in hypothalamic POMC neurons impairs lipolysis

Kaushik, S., Arias, E., Kwon, H., Lopez, N. M., Athonvarangkul, D., Sahu, S., Schwartz, G. J., Pessin, J. E. & Singh, R., Mar 2012, In: EMBO Reports. 13, 3, p. 258-265 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

157 Scopus citations

2011

Autophagy in hypothalamic agrp neurons regulates food intake and energy balance

Kaushik, S., Rodriguez-Navarro, J. A., Arias, E., Kiffin, R., Sahu, S., Schwartz, G. J., Cuervo, A. M. & Singh, R., Aug 3 2011, In: Cell metabolism. 14, 2, p. 173-183 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

295 Scopus citations

Constitutive upregulation of chaperone-mediated autophagy in Huntington's disease

Koga, H., Martinez-Vicente, M., Arias, E., Kaushik, S., Sulzer, D. & Cuervo, A. M., Dec 14 2011, In: Journal of Neuroscience. 31, 50, p. 18492-18505 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

132 Scopus citations

Microautophagy of Cytosolic Proteins by Late Endosomes

Sahu, R., Kaushik, S., Clement, C. C., Cannizzo, E. S., Scharf, B., Follenzi, A., Potolicchio, I., Nieves, E., Cuervo, A. M. & Santambrogio, L., Jan 18 2011, In: Developmental cell. 20, 1, p. 131-139 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

659 Scopus citations

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

Yang, D. S., Stavrides, P., Mohan, P. S., Kaushik, S., Kumar, A., Ohno, M., Schmidt, S. D., Wesson, D., Bandyopadhyay, U., Jiang, Y., Pawlik, M., Peterhoff, C. M., Yang, A. J., Wilson, D. A., St George-Hyslop, P., Westaway, D., Mathews, P. M., Levy, E., Cuervo, A. M. & Nixon, R. A., Jan 2011, In: Brain. 134, 1, p. 258-277 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

372 Scopus citations

2010

Altered lipid content inhibits autophagic vesicular fusion

Koga, H., Kaushik, S. & Cuervo, A. M., Aug 2010, In: FASEB Journal. 24, 8, p. 3052-3065 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

346 Scopus citations

Autophagic pathways and metabolic stress

Kaushik, S., Singh, R. & Cuervo, A. M., Oct 2010, In: Diabetes, Obesity and Metabolism. 12, SUPPL. 2, p. 4-14 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

71 Scopus citations

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

Martinez-Vicente, M., Talloczy, Z., Wong, E., Tang, G., Koga, H., Kaushik, S., De Vries, R., Arias, E., Harris, S., Sulzer, D. & Cuervo, A. M., May 2010, In: Nature Neuroscience. 13, 5, p. 567-576 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

681 Scopus citations

Chronic ingestion of 2-deoxy-d-glucose induces cardiac vacuolization and increases mortality in rats

Minor, R. K., Smith, D. L., Sossong, A. M., Kaushik, S., Poosala, S., Spangler, E. L., Roth, G. S., Lane, M., Allison, D. B., de Cabo, R., Ingram, D. K. & Mattison, J. A., Mar 15 2010, In: Toxicology and Applied Pharmacology. 243, 3, p. 332-339 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

105 Scopus citations

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

Lee, J. Y., Koga, H., Kawaguchi, Y., Tang, W., Wong, E., Gao, Y. S., Pandey, U. B., Kaushik, S., Tresse, E., Lu, J., Taylor, J. P., Cuervo, A. M. & Yao, T. P., Mar 2010, In: EMBO Journal. 29, 5, p. 969-980 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

621 Scopus citations

Identification of Regulators of Chaperone-Mediated Autophagy

Bandyopadhyay, U., Sridhar, S., Kaushik, S., Kiffin, R. & Cuervo, A. M., Aug 2010, In: Molecular Cell. 39, 4, p. 535-547 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

165 Scopus citations

Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation

Wang, Y., Martinez-Vicente, M., Krüger, U., Kaushik, S., Wong, E., Mandelkow, E. M., Cuervo, A. M. & Mandelkow, E., Jan 1 2010, In: Autophagy. 6, 1, p. 182-183 2 p.

Research output: Contribution to journal › Article › peer-review

Open Access

78 Scopus citations

Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy

Rothenberg, C., Srinivasan, D., Mah, L., Kaushik, S., Peterhoff, C. M., Ugolino, J., Fang, S., Cuervo, A. M., Nixon, R. A. & Monteiro, M. J., Jun 7 2010, In: Human molecular genetics. 19, 16, p. 3219-3232 14 p., ddq231.

Research output: Contribution to journal › Article › peer-review

Open Access

190 Scopus citations

2009

Autophagy regulates lipid metabolism

Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M. & Czaja, M. J., Apr 30 2009, In: Nature. 458, 7242, p. 1131-1135 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2992 Scopus citations

Tau fragmentation, aggregation and clearance: The dual role of lysosomal processing

Wang, Y., Martinez-Vicente, M., Krüger, U., Kaushik, S., Wong, E., Mandelkow, E. M., Cuervo, A. M. & Mandelkow, E., 2009, In: Human molecular genetics. 18, 21, p. 4153-4170 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

499 Scopus citations

2008

Chaperone-mediated autophagy.

Kaushik, S. & Cuervo, A. M., 2008, In: Methods in molecular biology (Clifton, N.J.). 445, p. 227-244 18 p.

Research output: Contribution to journal › Article › peer-review

Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy

Kaushik, S., Massey, A. C., Mizushima, N. & Cuervo, A. M., May 2008, In: Molecular biology of the cell. 19, 5, p. 2179-2192 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

273 Scopus citations

Dopamine-modified α-synuclein blocks chaperone-mediated autophagy

Martinez-Vicente, M., Talloczy, Z., Kaushik, S., Massey, A. C., Mazzulli, J., Mosharov, E. V., Hodara, R., Fredenburg, R., Wu, D. C., Follenzi, A., Dauer, W., Przedborski, S., Ischiropoulos, H., Lansbury, P. T., Sulzer, D. & Cuervo, A. M., Feb 1 2008, In: Journal of Clinical Investigation. 118, 2, p. 777-778 2 p.

Research output: Contribution to journal › Article › peer-review

Open Access

575 Scopus citations

Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus

Wang, Y., Singh, R., Massey, A. C., Kane, S. S., Kaushik, S., Grant, T., Xiang, Y., Cuervo, A. M. & Czaja, M. J., Feb 22 2008, In: Journal of Biological Chemistry. 283, 8, p. 4766-4777 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

122 Scopus citations

The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane

Bandyopadhyay, U., Kaushik, S., Varticovski, L. & Cuervo, A. M., Sep 2008, In: Molecular and cellular biology. 28, 18, p. 5747-5763 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

406 Scopus citations

2007

Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age

Kiffin, R., Kaushik, S., Zeng, M., Bandyopadhyay, U., Zhang, C., Massey, A. C., Martinez-Vicente, M. & Cuervo, A. M., Mar 1 2007, In: Journal of cell science. 120, 5, p. 782-791 10 p.

Research output: Contribution to journal › Article › peer-review