Personal profile
Keywords
- RZ Other systems of medicine
- Microbiome
- Health
- orphan nuclear receptors
- inflammatory bowel disease
- colon cancer
- probiotics
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Grants
- 11 Finished
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Developmental PBDE exposure, gut microbiome, and diabetes
Mani, S. (CoPI)
1/1/19 → 12/31/21
Project: Research project
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Microbial Metabolite Mimics, PXR and Colitis-Induced Colorectal Cancer
Mani, S. (PI) & Mani, S. (CoPI)
8/14/18 → 7/31/23
Project: Research project
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Microbial Metabolite Mimics, PXR and Colitis-Induced Colorectal Cancer
Mani, S. (PI)
8/14/18 → 7/31/22
Project: Research project
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Microbial Metabolite Mimics, PXR and Colitis-Induced Colorectal Cancer
Mani, S. (PI)
8/14/18 → 7/31/21
Project: Research project
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Development of Novel Drugs to Alleviate CPT-11 Toxicity
Mani, S. (CoPI), Redinbo, M. R. (CoPI) & Mani, S. (PI)
4/1/12 → 3/31/15
Project: Research project
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An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice
Wang, X., Zhang, G., Bian, Z., Chow, V., Grimaldi, M., Carivenc, C., Sirounian, S., Li, H., Sladekova, L., Stefano, M., Luperi, Y., Gong, Y., Costello, C., Li, L., Jachimowicz, M., Guo, M., Hu, S., Wilson, D., Balaguer, P. & Bourguet, W. & 8 others, , Dec 2025, In: Nature communications. 16, 1, 1280.Research output: Contribution to journal › Article › peer-review
Open Access18 Link opens in a new tab Scopus citations -
Correction to: An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice (Nature Communications, (2025), 16, 1, (1280), 10.1038/s41467-025-56624-0)
Wang, X., Zhang, G., Bian, Z., Chow, V., Grimaldi, M., Carivenc, C., Sirounian, S., Li, H., Sladekova, L., Motta, S., Luperi, Y., Gong, Y., Costello, C., Li, L., Jachimowicz, M., Guo, M., Hu, S., Wilson, D., Balaguer, P. & Bourguet, W. & 8 others, , Dec 2025, In: Nature communications. 16, 1, 2133.Research output: Contribution to journal › Comment/debate › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Cytoplasmic PXR regulates glucose metabolism by binding mRNAs and modulating their stability
Wang, X., Wang, Z., Li, S., Pattarayan, D., Wang, Y., Zhai, J., Zhang, Y., Wang, H., Xu, M., Zhu, J., Wang, J., Ma, X., Mani, S., Xie, W., Zhang, M. & Yang, D., Nov 2025, In: Nature Structural and Molecular Biology. 32, 11, p. 2144-2157 14 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations -
Decoding structural determinants of aryl hydrocarbon receptor antagonism by monoterpenoids
Zůvalová, I., Vyhlídalová, B., Ondrová, K., Nádvorník, P., Hrubý, J., Illés, P., Soural, M., Šebela, M., Šindlerová, L., Kubala, L., Mani, S. & Dvořák, Z., Apr 2025, In: Bioorganic Chemistry. 157, 108265.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations -
Deep learning-based detection of bacterial swarm motion using a single image
Li, Y., Li, H., Chen, W., O’Riordan, K., Mani, N., Qi, Y., Liu, T., Mani, S. & Ozcan, A., 2025, In: Gut Microbes. 17, 1, 2505115.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations