Projects per year
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Collaborations and top research areas from the last five years
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Structure and Mechanism of the Kinesin-3 Motor KIF1A
Gennerich, A. (PI) & Sosa, H. J. (CoPI)
National Institute of General Medical Sciences
9/1/23 → 6/30/27
Project: Research project
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Mechanism of Microtubule Dynamics Regulation by Kinesins
Sosa, H. H. J. (PI), Sosa, H. H. J. (CoPI) & Sosa, H. J. (CoPI)
National Institute of General Medical Sciences
3/1/15 → 5/31/27
Project: Research project
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MECHANISM OF MICROTUBULE DYNAMICS REGULATION BY KINESINS
Sosa, H. J. (PI)
3/1/15 → 1/31/22
Project: Research project
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Phosphoregulation of the Kinesin Motor Domain: Structure, Dynamics and Function
Gerfen, G. J. (CoPI), Ma, A. (CoPI), Sharp, D. J. (CoPI), Sosa, H. J. (CoPI) & Sosa, H. J. (PI)
National Institute of General Medical Sciences
5/1/12 → 4/30/16
Project: Research project
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Phosphoregulation of the Kinesin Motor Domain: Structure, Dynamics and Function
Ma, A. O. (PI), Ma, A. O. (PI), Sharp, D. J. (CoPI), Gerfen, G. J. (PI), Sosa, H. J. (CoPI), Rose, S. A. (PI), Rose, S. A. (PI), Rose, S. A. (PI), Rose, S. A. (PI), Rose, S. A. (PI), Rose, S. A. (PI), Rose, S. A. (PI) & Rose, S. A. (PI)
5/1/12 → 4/30/16
Project: Research project
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Beyond Binding Affinity: How a Conformation-Specific Salt Bridge Tunes KIF1A Mechanochemistry
Shatarupa, A., Rao, L., Gennerich, A. & Sosa, H., 2026, (Accepted/In press) In: Cytoskeleton.Research output: Contribution to journal › Article › peer-review
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Pathogenic KIF1A R350 mutations disrupt a conserved and conformation-dependent kinesin-tubulin salt bridge
Shatarupa, A., Rao, L., Asenjo, A. B., Gennerich, A. & Sosa, H., Dec 2026, In: Nature communications. 17, 1, 5175.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Cryo-EM unveils kinesin KIF1A’s processivity mechanism and the impact of its pathogenic variant P305L
Benoit, M. P. M. H., Rao, L., Asenjo, A. B., Gennerich, A. & Sosa, H., Dec 2024, In: Nature communications. 15, 1, 5530.Research output: Contribution to journal › Article › peer-review
Open Access15 Link opens in a new tab Scopus citations -
New insights into the mechanochemical coupling mechanism of kinesin-microtubule complexes from their high-resolution structures
Benoit, M. P. M. H., Hunter, B., Allingham, J. S. & Sosa, H., Aug 2023, In: Biochemical Society transactions. 51, 4, p. 1505-1520 16 p.Research output: Contribution to journal › Review article › peer-review
Open Access11 Link opens in a new tab Scopus citations -
Nucleotide-free structures of KIF20A illuminate atypical mechanochemistry in this kinesin-6
Ranaivoson, F. M., Crozet, V., Benoit, M. P. M. H., Abdalla Mohammed Khalid, A., Kikuti, C., Sirkia, H., El Marjou, A., Miserey-Lenkei, S., Asenjo, A. B., Sosa, H., Schmidt, C. F., Rosenfeld, S. S. & Houdusse, A., Sep 20 2023, In: Open Biology. 13, 9, 230122.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Scopus citations